Factors associated with infant sex and preterm birth status for selected birth defects from the National Birth Defects Prevention Study, 1997-2011.
Factors associated with infant sex and preterm birth status for selected birth defects from the National Birth Defects Prevention Study, 1997-2011.
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1997-2011 年国家出生缺陷预防研究中与婴儿性别和特定出生缺陷早产状况相关的因素。
DOI：
10.1002/bdr2.2294
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发表时间：
2024
影响因子：
2.1
通讯作者：
NationalBirthDefe
中科院分区：
文献类型：
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作者：
Williford,EvaM;Yang,Wei;Howley,MeredithM;Ma,Chen;Collins,RonnieT;Weber,KariA;Heinke,Dominique;Petersen,JulieM;Agopian,AJ;Archer,NatalieP;Olshan,AndrewF;Williams,LindsayA;Browne,MarilynL;Shaw,GaryM;NationalBirthDefe
背景出生缺陷和早产同时发生，并且存在一些重叠的危险因素。许多出生缺陷和早产往往以男性为主。我们利用国家出生缺陷预防研究 (NBDPS) 的数据，探讨了影响 1997 年至 2011 年期间出生的特定出生缺陷婴儿的性别和早产（妊娠 <37 周）出生差异的潜在风险因素。方法 NBDPS 是一项大型多中心、基于人群的病例对照研究。使用随机森林，我们确定了男性早产、女性早产和男性足月的重要预测因子，并将每个出生缺陷与女性足月产进行了比较。使用逻辑回归，我们估计了出生缺陷的重要预测因素与性别早产状况之间关联的比值比。结果我们检查了 11,379 名患有 9 种特定出生缺陷的婴儿。随机森林中的前 10 个最重要的性早产状况预测因子在特定缺陷组内的出生缺陷和性早产比较中差异很大，其中有几个是新因素。然而，一个一致性是，对于许多研究的出生缺陷来说，较短的妊娠间隔与性早产状态相关。尽管在其他研究中肥胖已被确定为早产和出生缺陷的危险因素，但它与任何所检查的缺陷的性别早产状况均无关。结论我们证实了性别早产状况差异的预期关联，并在所研究的出生缺陷中发现了新的潜在危险因素，有待进一步探索。
BackgroundBirth defects and preterm birth co‐occur, with some overlapping risk factors. Many birth defects and preterm births tend to have a male preponderance. We explored potential risk factors impacting sex and preterm (<37 weeks of gestation) birth differences among infants with selected birth defects delivered from 1997 to 2011 using data from the National Birth Defects Prevention Study (NBDPS).MethodsThe NBDPS was a large multisite, population‐based case–control study. Using random forests, we identified important predictors of male preterm, female preterm, and male term, each compared with female term births for each birth defect. Using logistic regression, we estimated odds ratios for associations between important predictors and sex‐preterm birth status by birth defect.ResultsWe examined 11,379 infants with nine specific birth defects. The top 10 most important predictors of sex‐preterm birth status from the random forests varied greatly across the birth defects and sex‐preterm comparisons within a given defect group, with several being novel factors. However, one consistency was that short interpregnancy interval was associated with sex‐preterm birth status for many of the studied birth defects. Although obesity has been identified as a risk factor for preterm birth and birth defects in other research, it was not associated with sex‐preterm birth status for any of the examined defects.ConclusionsWe confirmed expected associations for sex‐preterm birth status differences and found new potential risk factors for further exploration among the studied birth defects.