The levels of liver enzymes and atypical lymphocytes are higher in youth patients with infectious mononucleosis than in preschool children.
The levels of liver enzymes and atypical lymphocytes are higher in youth patients with infectious mononucleosis than in preschool children.
复制标题
患有传染性单核细胞增多症的青年患者的肝酶和非典型淋巴细胞水平高于学龄前儿童
DOI：
10.3350/cmh.2013.19.4.382
复制
发表时间：
2013-12
影响因子：
8.9
通讯作者：
Zhao H
中科院分区：
文献类型：
--
作者：
Wang Y;Li J;Ren YY;Zhao H
背景/目的传染性单核细胞增多症（IM）是原发性感染eb病毒的临床表现。尽管文献中包含了大量关于即时通讯的信息，但其中大多数都是专门针对儿童或成人的。为了区分学龄前儿童和青少年患者之间的差异，我们回顾性分析了他们的人口学和临床特征。方法检索2001年12月至2011年9月在北京大学附属三级教学医院北京大学第一医院就诊的诊断为IM的患者病历。收集患者的人口学资料和临床特征。结果10年间确诊IM 287例，发病率以学龄前儿童（≤7岁，130/287,45.3%）和青年患者（15岁及<24岁，101/287,35.2%）居多。虽然入院时的主诉在两组患者之间没有差异，但临床症状（扁桃体咽炎、淋巴结病、肝肿大和眼睑水肿）在学龄前儿童中的发病率要高得多。青年组肝脏病变发生率和非典型淋巴细胞百分比显著高于青年组（P<0.001），且平均住院时间更长。肺炎是最常见的并发症，无死亡病例。结论北京市学龄前儿童和青少年IM发病率最高。肝酶和非典型淋巴细胞水平随着年龄的增长而增加。
Background/Aims Infectious mononucleosis (IM) is the clinical presentation of primary infection with Epstein-Barr virus. Although the literature contains a massive amount of information on IM, most of this is related specifically to only children or adults separately. In order to distinguish any differences between preschool children and youth patients, we retrospectively analyzed their demographic and clinical features. Methods Records of patients hospitalized from December 2001 to September 2011 with a diagnosis of IM were retrieved from Peking University First Hospital, which is a tertiary teaching hospital in Beijing. The demographic data and clinical characteristics were collected. Results IM was diagnosed in 287 patients during this 10-year period, with incidence peaks among preschool children (≤7 years old, 130/287, 45.3%) and youth patients (>15 and <24 years old, 101/287, 35.2%). Although the complaints at admission did not differ between these two patient groups, the incidence of clinical signs (tonsillopharyngitis, lymphadenopathy, hepatomegaly, and edema of the eyelids) was much higher in preschool children. The incidence of liver lesion and percentage of atypical lymphocytes were significantly higher in the youth group (P<0.001), and the average hospital stay was longer in this group. Pneumonia was the most common complication, and there was no case of mortality. Conclusions The incidence of IM peaks among preschool children and youth patients in Beijing, China. The levels of liver enzymes and atypical lymphocytes increase with age.