2 DISTINCT TRANSCRIPTION FACTORS THAT BIND THE IMMUNOGLOBULIN ENHANCER MU-E5/KE2 MOTIF
2 DISTINCT TRANSCRIPTION FACTORS THAT BIND THE IMMUNOGLOBULIN ENHANCER MU-E5/KE2 MOTIF
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DOI：
10.1126/science.2105528
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发表时间：
1990-01-26
期刊：
影响因子：
56.9
通讯作者：
KADESCH, T
中科院分区：
文献类型：
--
作者：
HENTHORN, P;KILEDJIAN, M;KADESCH, T
免疫球蛋白重链和κ的活性轻链基因增强子依赖于普遍存在的和发育调节的蛋白质的复杂相互作用。分离了编码蛋白质的两种互补DNA，称为ITF-1和ITF-2，其在多种细胞类型中表达并结合在重链和κ中发现的μ E5/κ E2基序。轻链增强剂。互补DNA是不同基因的产物，然而ITF-1和ITF-2两者在结构和功能上相似。这两种蛋白质通过它们假定的螺旋-环螺旋基序相互作用，并且各自具有决定转录激活的不同结构域。
Activity of the immunoglobulin heavy and .kappa. light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins. Two complementary DNAs were isolated that encode proteins, denoted ITF-l and ITF-2, that are expressed in a variety of cell types and bind the .mu.E5/.kappa.E2 motif found in both heavy and .kappa. light chain enhancers. The complementary DNAs are the products of distinct genes, yet both ITF-l and ITF-2 are structurally and functionally similar. The two proteins interact with one another through their putative helix-loop helix motifs and each possesses a distinct domain that dictates transcription activation.