Complications of treatment encountered in lymphoma‐leukemia long‐term survivors
Complications of treatment encountered in lymphoma‐leukemia long‐term survivors
复制标题
淋巴瘤-白血病长期幸存者遇到的治疗并发症
作者：
G. D'angio
淋巴瘤和白血病患者的潜在治疗后并发症包括：1）儿童生长和发育受损，2）CNS紊乱，包括心理、智力和神经表现，3）性腺效应-内分泌、生殖、致畸和遗传，4）其他器官和结构功能障碍，如甲状腺、肺和心脏，以及5）肿瘤发生。许多这些不利因素都是由放射治疗消除的，但化疗也可能导致一些长期的有害后果。联合化疗和放射治疗的结果正变得越来越好理解，并需要进一步阐明，因为疾病的早期阶段正在通过联合化疗和放射治疗方案进行管理。
Potential posttreatment complications for patients with the lymphomas and leukemia include: 1) impairment of growth and development in children, 2) CNS disturbances encompassing psychologic, intellectual and neurologic expressions, 3) gonadal effects—endocrine, reproductive, teratogenic and genetic, 4) dysfunction of other organs and structures, such as the thyroid, lung and heart, and 5) oncogenesis. Many of these adversities are occasioned by radiation therapy, but chemotherapy also can be responsible for some long‐term deleterious consequences. The results of combined chemo‐ and radiation therapy are becoming better understood, and require further elucidation because earlier stages of the disease are being managed by combined chemo‐ and radiation therapy regimens.