Golgi Bypass: Skirting Around the Heart of Classical Secretion
Golgi Bypass: Skirting Around the Heart of Classical Secretion
复制标题
DOI：
10.1101/cshperspect.a005298
复制
发表时间：
2011-04-01
影响因子：
7.2
通讯作者：
Rabouille, Catherine
中科院分区：
文献类型：
--
作者：
Grieve, Adam G.;Rabouille, Catherine
经典分泌由分别将跨膜和可溶性蛋白质递送至质膜和细胞外介质组成，并且由分泌途径的细胞器、内质网（ER）、ER出口位点和高尔基体介导，如诺贝尔奖赢家乔治帕拉德（Palade 1975）所述。在这条运输路线的中心，高尔基体堆栈在修改，加工，分选和调度新合成的蛋白质到其最终目的地方面发挥着重要作用。然而，最近已经清楚，越来越多的跨膜蛋白以非常规方式到达质膜，要么通过在非COPII囊泡中离开ER，要么绕过高尔基体。在这里，我们讨论的证据高尔基体旁路和可能的生理效益it.Intriguingly，至少在果蝇的发展，高尔基体旁路似乎是介导的高尔基体蛋白，dGRASP，发现异位定位于质膜。
Classical secretion consists of the delivery of transmembrane and soluble proteins to the plasma membrane and the extracellular medium, respectively, and is mediated by the organelles of the secretory pathway, the Endoplasmic Reticulum (ER), the ER exit sites, and the Golgi, as described by the Nobel Prize winner George Palade (Palade 1975). At the center of this transport route, the Golgi stack has a major role in modifying, processing, sorting, and dispatching newly synthesized proteins to their final destinations. More recently, however, it has become clear that an increasing number of transmembrane proteins reach the plasma membrane unconventionally, either by exiting the ER in non-COPII vesicles or by bypassing the Golgi. Here, we discuss the evidence for Golgi bypass and the possible physiological benefits of it. Intriguingly, at least during Drosophila development, Golgi bypass seems to be mediated by a Golgi protein, dGRASP, which is found ectopically localized to the plasma membrane.