Interferon and spontaneous cytotoxicity in man. V. Enhancement of spontaneous cytotoxicity in patients receiving human leukocyte interferon
Interferon and spontaneous cytotoxicity in man. V. Enhancement of spontaneous cytotoxicity in patients receiving human leukocyte interferon
复制标题
干扰素和人体自发细胞毒性。
DOI：
10.1002/ijc.2910260406
复制
发表时间：
1980
影响因子：
6.4
通讯作者：
H. Strander
中科院分区：
文献类型：
--
作者：
S. Einhorn;H. Blomgren;H. Strander
本文观察了43例不同疾病患者每日注射3 × 106单位人白细胞干扰素（IF）对外周血淋巴细胞自发杀伤活性的影响。在第一次IF注射后12至24小时观察到自发细胞毒性增加，在大多数情况下，在24小时出现活性峰值。在一些患者中，在注射后6小时观察到自发细胞毒性降低，在此之前增加。自发细胞毒性的增加与注射前细胞毒性水平、疾病、年龄、性别、既往治疗、白细胞计数或淋巴细胞和单核细胞比例无显著相关性。第二次注射IF使自发细胞毒性保持在增加的水平，并且在延长的IF治疗期间，长达9个月，细胞毒性仍然升高。IF治疗在体外引起的增强自发细胞毒性的淋巴细胞之前，IF注射。这种IF诱导的体外细胞毒性增加与IF诱导的体内细胞毒性增加相关。在第一次IF注射后6小时，IF在体外增强自发细胞毒性的能力降低，并且在长期治疗期间，IF在体外增强自发细胞毒性的能力仍然降低。
The effect of daily injections of 3 × 106 units of human leukocyte IF on the spontaneous cytotoxicity of peripheral lymphocytes was studied in 43 patients with a variety of diseases. An increase in spontaneous cytotoxicity was observed 12 to 24 h after the first IF injection with the peak of activity occurring, in most cases, at 24 h. In some patients a decrease in spontaneous cytotoxicity, observed 6 h after the injection, preceded this increase. The increment in spontaneous cytotoxicity was not significantly correlated to preinjection level of cytotoxicity, disease, age, sex, previous therapy, leukocyte counts or proportions of lymphocytes and monocytes. A second injection of IF maintained the spontaneous cytotoxicity at an increased level and during prolonged IF therapy, up to 9 months, the cytotoxicity remained elevated. IF treatment in vitro caused an enhancement of spontaneous cytotoxicity in lymphocytes drawn prior to IF injection. This IF‐induced increase in cytotoxicity in vitro was correlated to the increase in cytototoxicity induced by IF in vivo. Six hours after the first IF injection the ability of IF in vitro to enhance spontaneous cytotoxicity was decreased and during prolonged therapy the ability of IF in vitro to enhance spontaneous cytotoxicity remained decreased.