Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system.
Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system.
复制标题
脑脊液系统顺应性和流出阻力的房室分析。
作者：
A. Marmarou;K. Shulman;J. Lamorgese
通过分析脑脊液（CSF）压力对脑脊液体积变化的反应，测量麻醉、通气猫的脑室和脊髓室之间的顺应性和流出阻力的分布。通过给位于硬膜外 C-6 水平的气球充气来分离大脑和脊髓室。通过将实验响应的压力数据插入由数学模型开发的一系列方程中，评估每单位压力变化（顺应性）的脑脊液体积变化和每单位时间的脑脊液体积变化（吸收）。结果发现，68% 的总顺应性由脑室贡献，而其余 32% 则包含在脊柱轴内。脑室占脑脊液吸收总量的84%。脊柱吸收的机制似乎相似，在压力动力学的基础上没有明显的差异。
The distribution of compliance and outflow resistance between cerebral and spinal compartments was measured in anesthetized, ventilated cats by analysis of the cerebrospinal fluid (CSF) pressure response to changes in CSF volume. Cerebral and spinal compartments were isolated by inflating a balloon positioned epidurally at the level of C-6. The change of CSF volume per unit change in pressure (compliance) and change of CSF volume per unit of time (absorption) were evaluated by inserting pressure data from the experimental responses into a series of equations developed from a mathematical model. It was found that 68% of total compliance is contributed by the cerebral compartment while the remaining 32% is contained within the spinal axis. The cerebral compartment accounted for 84% of total CSF absorption. The mechanism for spinal absorption appears to be similar in that no differences were obvious on the basis of pressure dynamics.