Association of Prenatal Exposure to Persistent Organic Pollutants with Obesity and Cardiometabolic Traits in Early Childhood: The Rhea Mother-Child Cohort (Crete, Greece).
Association of Prenatal Exposure to Persistent Organic Pollutants with Obesity and Cardiometabolic Traits in Early Childhood: The Rhea Mother-Child Cohort (Crete, Greece).
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DOI：
10.1289/ehp.1409062
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发表时间：
2015-10
影响因子：
10.4
通讯作者：
Chatzi L
中科院分区：
文献类型：
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作者：
Vafeiadi M;Georgiou V;Chalkiadaki G;Rantakokko P;Kiviranta H;Karachaliou M;Fthenou E;Venihaki M;Sarri K;Vassilaki M;Kyrtopoulos SA;Oken E;Kogevinas M;Chatzi L
产前接触持久性有机污染物 (POP) 等内分泌干扰化学物质可能会增加日后肥胖的风险。我们在希腊克里特岛的 Rhea 母子队列 (n = 689) 中研究了子宫内 POP 暴露与后代肥胖和 4 岁时心脏代谢危险因素的关系。我们测定了妊娠早期母体血清中多氯联苯 (PCB)、二氯二苯基二氯乙烯 (DDE) 和六氯苯 (HCB) 的浓度。我们测量了 4 岁时儿童的体重、身高、腰围、皮褶厚度、血压 (BP)、血脂、C 反应蛋白和脂肪因子水平。根据国际肥胖工作组的建议，儿童肥胖是使用特定于年龄和性别的体重指数 (BMI) 切点来定义的。在多变量回归分析中，HCB 增加 10 倍与较高的 BMI z 得分（调整后的 β = 0.49；95% CI：0.12，0.86）、肥胖[相对风险 (RR) = 8.14；相对风险 (RR) = 8.14；相对风险 (RR) = 8.14] 相关。 95% CI: 1.85, 35.81]、腹部肥胖 (RR = 3.49; 95% CI: 1.08, 11.28)、更大的皮褶厚度总和 (β = 7.71 mm; 95% CI: 2.04, 13.39) 和较高的收缩压 (β = 4.34 mmHg; 95% CI: 0.63, 8.05) 4岁时。产前 DDE 暴露与较高的 BMI z 值（β = 0.27；95% CI：0.04，0.5）、腹部肥胖（RR = 3.76；95% CI：1.70，8.30）和较高的舒张压（β = 1.79 mmHg；95% CI：0.13，3.46）相关。 PCB 与后代肥胖或心脏代谢危险因素没有显着相关性。产前接触 DDE 和 HCB 与儿童早期过度肥胖和血压升高有关。 Vafeiadi M, Georgiou V, Chalkiadaki G, Rantakokko P, Kiviranta H, Karachaliou M, Fthenou E, Venihaki M, Sarri K, Vassilaki M, Kyrtopoulos SA, Oken E, Kogevinas M, Chatzi L. 2015。产前接触持久性有机污染物与儿童早期肥胖和心脏代谢特征的关联：Rhea 母子队列（希腊克里特岛）。环境健康视角123：1015–1021； http://dx.doi.org/10.1289/ehp.1409062
Prenatal exposure to endocrine-disrupting chemicals such as persistent organic pollutants (POPs) may increase risk of obesity later in life. We examined the relation of in utero POPs exposure to offspring obesity and cardiometabolic risk factors at 4 years of age in the Rhea mother–child cohort in Crete, Greece (n = 689). We determined concentrations of polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) in first-trimester maternal serum. We measured child weight, height, waist circumference, skinfold thicknesses, blood pressure (BP), blood levels of lipids, C-reactive protein, and adipokines at 4 years of age. Childhood obesity was defined using age- and sex-specific cut points for body mass index (BMI) as recommended by the International Obesity Task Force. On multivariable regression analyses, a 10-fold increase in HCB was associated with a higher BMI z-score (adjusted β = 0.49; 95% CI: 0.12, 0.86), obesity [relative risk (RR) = 8.14; 95% CI: 1.85, 35.81], abdominal obesity (RR = 3.49; 95% CI: 1.08, 11.28), greater sum of skinfold thickness (β = 7.71 mm; 95% CI: 2.04, 13.39), and higher systolic BP (β = 4.34 mmHg; 95% CI: 0.63, 8.05) at 4 years of age. Prenatal DDE exposure was associated with higher BMI z-score (β = 0.27; 95% CI: 0.04, 0.5), abdominal obesity (RR = 3.76; 95% CI: 1.70, 8.30), and higher diastolic BP (β = 1.79 mmHg; 95% CI: 0.13, 3.46). PCBs were not significantly associated with offspring obesity or cardiometabolic risk factors. Prenatal exposure to DDE and HCB was associated with excess adiposity and higher blood pressure levels in early childhood. Vafeiadi M, Georgiou V, Chalkiadaki G, Rantakokko P, Kiviranta H, Karachaliou M, Fthenou E, Venihaki M, Sarri K, Vassilaki M, Kyrtopoulos SA, Oken E, Kogevinas M, Chatzi L. 2015. Association of prenatal exposure to persistent organic pollutants with obesity and cardiometabolic traits in early childhood: the Rhea mother–child cohort (Crete, Greece). Environ Health Perspect 123:1015–1021; http://dx.doi.org/10.1289/ehp.1409062