Physiological and pathological skeletal muscle T1 changes quantified using a fast inversion-recovery radial NMR imaging sequence
Physiological and pathological skeletal muscle T1 changes quantified using a fast inversion-recovery radial NMR imaging sequence
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DOI：
10.1038/s41598-019-43398-x
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发表时间：
2019-05-02
影响因子：
4.6
通讯作者：
Carlier, Pierre G.
中科院分区：
文献类型：
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作者：
Marty, Benjamin;Carlier, Pierre G.
我们研究了在不同的生理和病理条件下骨骼肌的整体T1的反应，使用反转恢复径向T1映射序列。研究了35例健康志愿者、7例Becker型肌营养不良症（BMD）和7例散发性包涵体肌炎（IBM）患者的T1值，以评价性别、年龄、肌群、运动和病理过程对T1值的影响。此外，使用3点狄克逊测量肌内脂肪含量，并使用多自旋回波序列确定整体T2和水T2（T2（H2O））。在健康志愿者的肌肉中，年龄对整体T1没有影响。然而，我们测量了性别和肌肉群的显着影响。运动后，一个显着的7.7%的增加，全球T1测量招募的肌肉，全球T1的变化高度相关的T-2 H2O的变化（R = 0.91）。在病理学中，脂肪浸润肌肉的整体T1值降低。当考虑脂肪分数时，IBM患者的总体T1值高于BMD。整体T1变化是骨骼肌中与几种生理和病理事件相关的组织变化的敏感指标。
We investigated the response of skeletal muscle global T1 under different physiological and pathological conditions using an inversion-recovery radial T1 mapping sequence. Thirty five healthy volunteers, seven patients with Becker muscular dystrophy (BMD) and seven patients with sporadic inclusion body myositis (IBM) were investigated in order to evaluate the effects of gender, age, muscle group, exercise and pathological processes on global T1 values. In addition, the intramuscular fat content was measured using 3-point Dixon and the global T2 and water T2 (T2(H2O)) were determined with a multi-spin-echo sequence. In the muscles of healthy volunteers, there was no impact of age on global T1. However, we measured a significant effect of sex and muscle group. After exercise, a significant 7.7% increase of global T1 was measured in the recruited muscles, and global T1 variations were highly correlated to T-2H2O variations (R = 0.91). In pathologies, global T1 values were reduced in fat infiltrated muscles. When fat fraction was taken into account, global T1 values were higher in IBM patients compared to BMD. Global T1 variations are a sensitive indicator of tissue changes in skeletal muscle related to several physiological and pathological events.