Acoustic angiography: a new imaging modality for assessing microvasculature architecture.
Acoustic angiography: a new imaging modality for assessing microvasculature architecture.
复制标题
DOI：
10.1155/2013/936593
复制
发表时间：
2013
影响因子：
7.6
通讯作者：
Dayton PA
中科院分区：
文献类型：
--
作者：
Gessner RC;Frederick CB;Foster FS;Dayton PA
这篇论文的目的是向生物医学成像界提供一种新的高分辨率对比度成像方法的详细信息，该方法被称为“声学血管成像”。通过使用双频超声换能器技术，该方法获得的图像具有高分辨率和高对比度与组织比，从而能够在不需要背景组织显著贡献的情况下可视化微血管结构。此外，通过使用同一探头获取的b型覆盖层，可以可视化体积血管-组织整合。我们将简要介绍如何获取图像的技术概述，然后是健康组织体积和病变组织体积图像的几个例子。还包括临床前成像、对比度增强的微型CT和光声学中经常使用的替代模式的3D图像，以提供声学血管造影如何具有与这些其他技术定性相似的能力的视角。这些初步图像提供了令人信服的视觉证据，表明声学血管造影术可能在临床前和未来的临床成像中作为一种强大的新工具。
The purpose of this paper is to provide the biomedical imaging community with details of a new high resolution contrast imaging approach referred to as “acoustic angiography.” Through the use of dual-frequency ultrasound transducer technology, images acquired with this approach possess both high resolution and a high contrast-to-tissue ratio, which enables the visualization of microvascular architecture without significant contribution from background tissues. Additionally, volumetric vessel-tissue integration can be visualized by using b-mode overlays acquired with the same probe. We present a brief technical overview of how the images are acquired, followed by several examples of images of both healthy and diseased tissue volumes. 3D images from alternate modalities often used in preclinical imaging, contrast-enhanced micro-CT and photoacoustics, are also included to provide a perspective on how acoustic angiography has qualitatively similar capabilities to these other techniques. These preliminary images provide visually compelling evidence to suggest that acoustic angiography may serve as a powerful new tool in preclinical and future clinical imaging.