Tolerance to noninherited maternal antigens, reproductive microchimerism and regulatory T cell memory: 60 years after 'Evidence for actively acquired tolerance to Rh antigens'.
Tolerance to noninherited maternal antigens, reproductive microchimerism and regulatory T cell memory: 60 years after 'Evidence for actively acquired tolerance to Rh antigens'.
复制标题
对非遗传性母体抗原、生殖微嵌合和调节性 T 细胞记忆的耐受性：“主动获得对 Rh 抗原耐受性的证据”60 年后。
DOI：
10.1080/19381956.2015.1107253
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Way,SingSing
中科院分区：
文献类型：
--
作者：
Kinder,JeremyM;Jiang,TonyT;Ertelt,JamesM;Xin,Lijun;Strong,BeverlyS;Shaaban,AimenF;Way,SingSing
强制暴露于遗传性外源母体组织会导致后代对非遗传性母体抗原（NIMA）持续耐受。 Ray D. Owen 博士首次描述了对 NIMA 的免疫耐受性，对象是恒河猴红细胞 (Rh) 抗原基因阴性的女性，其母亲在发育过程中暴露于 Rh 导致的敏感性降低。将这一分析扩展到 HLA 单倍型，发现了利用哺乳动物生殖中天然存在的 NIMA 特异性耐受性进行治疗以改善同种异体移植后临床结果的令人兴奋的潜力。在此，我们总结了源自 NIMA 耐受性的新兴科学概念，包括后代微嵌合母体来源细胞的产后维持、具有 NIMA 特异性的免疫抑制调节 T 细胞的扩大积累，以及跨哺乳动物物种保守的 NIMA 特异性耐受性的目的学益处和免疫学后果。
Compulsory exposure to genetically foreign maternal tissue imprints in offspring sustained tolerance to noninherited maternal antigens (NIMA). Immunological tolerance to NIMA was first described by Dr. Ray D. Owen for women genetically negative for erythrocyte rhesus (Rh) antigen with reduced sensitization from developmental Rh exposure by their mothers. Extending this analysis to HLA haplotypes has uncovered the exciting potential for therapeutically exploiting NIMA-specific tolerance naturally engrained in mammalian reproduction for improved clinical outcomes after allogeneic transplantation. Herein, we summarize emerging scientific concepts stemming from tolerance to NIMA that includes postnatal maintenance of microchimeric maternal origin cells in offspring, expanded accumulation of immune suppressive regulatory T cells with NIMA-specificity, along with teleological benefits and immunological consequences of NIMA-specific tolerance conserved across mammalian species.