A novel aminoclay-curcumin hybrid for enhanced chemotherapy.
A novel aminoclay-curcumin hybrid for enhanced chemotherapy.
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DOI：
10.1039/c6tb00603e
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发表时间：
2016-06
期刊：
影响因子：
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通讯作者：
Suhang Wang;H. Cao;Yiming Zhong;Yuhong Yang;Z. Shao
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文献类型：
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作者：
Suhang Wang;H. Cao;Yiming Zhong;Yuhong Yang;Z. Shao
姜黄素（Curcumin，Cur）是一种有效的抗肿瘤药物。然而，其治疗应用在很大程度上受到其极低的水溶性、低稳定性和差的生物利用度的限制。本论文采用一锅法将姜黄素原位负载到氨基粘土上，制备了一种新型的氨基粘土-姜黄素杂化物。所得的杂化物易于剥离并易于分散在水性介质中。与游离Cur相比，AC-Cur杂化物在酸性和中性环境中的溶解度均显著提高，在中性和碱性环境中的稳定性均显著提高。更重要的是，该杂合物对各种肿瘤细胞系的治疗效果比游离Cur好得多，这主要归因于其显著改善的溶解性、稳定性和细胞摄取。我们的研究结果表明，这种具有高生物利用度的AC-Cur混合物可以潜在地应用于治疗恶性肿瘤的纳米医学。
Curcumin (Cur) has been demonstrated as an efficacious anti-tumor agent. However, its therapeutic applications are largely limited by its extremely low aqueous solubility, low stability and poor bioavailability. In this work, a simple one-pot synthesis was developed to fabricate a novel aminoclay-curcumin (AC-Cur) hybrid via the in situ loading of Cur over AC. The resultant hybrid was amenable to exfoliation and readily dispersible in aqueous media. Compared with free Cur, the AC-Cur hybrid displayed significantly enhanced solubility of Cur in both acidic and neutral environments, as well as enhanced stability of Cur in both neutral and alkaline environments. More importantly, this hybrid achieved a much better therapeutic effect than free Cur against various tumor cell lines, which was mainly attributed to its significantly improved solubility, stability and cellular uptake. Our results suggest that such an AC-Cur hybrid with high bioavailability can potentially be applied in nanomedicine for the treatment of malignant tumours.