Reference ranges for body composition indices by dual energy X-ray absorptiometry from the Bone Mineral Density in Childhood Study Cohort.
Reference ranges for body composition indices by dual energy X-ray absorptiometry from the Bone Mineral Density in Childhood Study Cohort.
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DOI：
10.1016/j.ajcnut.2023.08.006
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发表时间：
2023-10
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身体成分评估有助于评估能量储备以及疾病和干预措施对儿童成长的影响。目前美国儿科参考范围来自国家健康和营养检查调查(NHANES)，包括20%的肥胖儿童，体重指数≥95百分位数。这项研究旨在根据儿童骨密度研究(BMDCS)在低肥胖率的不同队列中建立基于双能X射线吸收法(DXA)的参考范围。这是对纵向、前瞻性、观察性队列的二次分析。来自5个美国中心的健康儿童(身高和体重指数在第3到97百分位数之间，注册时年龄在5-19岁)每年在≤7访问中进行测量。全身扫描是使用霍洛奇扫描仪进行的。一组样本进行了重复测量以确定精密度。我们生成了阑尾和总瘦软组织质量指数(LSTM指数)、脂肪质量指数(FMI)和其他身体成分测量的参考范围。将所得曲线与NHANES和跨亚组进行比较。建立了性别和年龄相关的方程，以调整身高Z分数的身体成分Z分数。我们获得了2011年参与者的9846次扫描(51%的女性，22%的黑人，17%的西班牙裔，48%的白人，7%的亚洲/太平洋岛民，6%的肥胖者)。精密度(变异系数百分比)为0.7%~1.96%。BMDCS和NHANES的中位数和-2标准差曲线相似，但NHANES+2标准差LSTM指数和FMI曲线明显大于各自的BMDCS曲线。与FMI-Z(西班牙裔0.2 9±0.98，黑人0.14±1.1)相比，附件LSTM指数-Z亚组差异更大(均值±SD：亚洲−0.5 2±0.93，黑人0.77±0.87)，校正高度Z-−的Z-SCORE较小。这些参考范围增加了关于儿童和青少年身体成分的稀疏标准数据，并基于肥胖流行率类似于当前BMI图表的队列。意识到亚组差异有助于解释结果。
Body composition assessment aids evaluation of energy stores and the impact of diseases and interventions on child growth. Current United States pediatric reference ranges from the National Health and Nutrition Examination Survey (NHANES) include 20% of children with obesity, body mass index of ≥95th percentile. This study aimed to develop dual energy X-ray absorptiometry (DXA) based reference ranges in a diverse cohort with low-obesity prevalence from the Bone Mineral Density in Childhood Study (BMDCS). This is a secondary analysis of a longitudinal, prospective, observational cohort. Healthy children (height and BMI within 3rd to 97th percentiles, ages 5–19 y at enrollment), from 5 United States centers were measured annually for ≤7 visits. Whole body scans were acquired using Hologic scanners. A subsample underwent repeat measurements to determine precision. We generated reference ranges for appendicular and total lean soft tissue mass index (LSTM Index), fat mass index (FMI), and other body composition measures. Resulting curves were compared to NHANES and across subgroups. Sex and age-specific equations were developed to adjust body composition Z-scores for height Z score. We obtained 9846 scans of 2011 participants (51% female, 22% Black, 17% Hispanic, 48% White, 7% Asian/Pacific Islander, and 6% with obesity). Precision (percent coefficient of variation) ranged from 0.7% to 1.96%. Median and–2 standard deviation curves for BMDCS and NHANES were similar, but NHANES +2 standard deviation LSTM Index and FMI curves were distinctly greater than the respective BMDCS curves. Subgroup differences were more extreme for appendicular LSTM Index-Z (mean ± SD: Asian −0.52 ± 0.93 compared with Black 0.77 ± 0.87) than for FMI-Z (Hispanic 0.29 ± 0.98 compared with Black −0.14 ± 1.1) and were smaller for Z-scores adjusted for height Z-score. These reference ranges add to sparse normative data regarding body composition in children and adolescents and are based on a cohort with an obesity prevalence similar to current BMI charts. Awareness of subgroup differences aids in interpreting results.
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影响因子：
3
作者：
Rudnev, Sergey;Burns, Jane S.;Sergeyev, Oleg
通讯作者：
Sergeyev, Oleg
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3.3
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Xu, Hao
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2
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GREEN, PJ
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2.5
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作者：
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Zemel, Babette S.