Effect of antipsychotics on regional cerebral blood flow measured with Positron Emission Tomography
Effect of antipsychotics on regional cerebral blood flow measured with Positron Emission Tomography
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DOI：
10.1016/s0893-133x(97)00042-0
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发表时间：
1997-10-01
影响因子：
7.6
通讯作者：
Hichwa, RD
中科院分区：
文献类型：
--
作者：
Miller, DD;Andreasen, NC;Hichwa, RD
局部脑血流 (rCBF) 的正电子发射断层扫描 (PET) 成像为研究脑功能提供了一种体内方法。我们使用 [O-15]H2O PET 来评估抗精神病药物对 17 名精神分裂症受试者的 rCBF 的影响。每个受试者在接受抗精神病药物治疗期间以及停用抗精神病药物治疗 3 周后均接受扫描。使用受试者内设计将两次扫描相减，并使用蒙特利尔方法确定差异区域。与“停药”状态相比，接受抗精神病药物治疗的受试者左侧基底神经节和左侧梭状回的 rCBF 显着升高。当停用抗精神病药物时，前扣带回、左背外侧和下额叶皮质以及左右小脑的相对 rCBF 显着升高。多巴胺 D-2 受体的上调可能导致基底神经节区域血流量和新陈代谢的增加，这可能解释了最近报道的这些区域的解剖学增大。 (C) 1997 年美国神经精神药理学学院。由爱思唯尔科学公司出版
Positron Emission Tomography (PET) imaging of regional cerebral blood flow (rCBF) provides an in vivo method for studying brain function. We used [O-15]H2O PET to assess the effect of antipsychotic medications on rCBF in 17 subjects with schizophrenia. Each subject was scanned whlle receiving antipsychotic medication, and after having been withdrawn from antipsychotic medication for a 3-week period. The two scans were subtracted from one another, using a within subjects design, and the areas of difference were identified using the Montreal method. Subjects treated with antipsychotic medication had significantly higher rCBF in the left basal ganglia and Ieft fusiform gyrus compared with the ''off-medication'' condition. Significantly higher relative rCBF in the anterior cingulate, left dorsolateral and inferior frontal cortex, and left and right cerebellum was observed when off antipsychotic medication. Upregulation of dopamine D-2 receptors may lead to a regional increase of blood flow and metabolism in the basal ganglia, which may explain recently reported anatomical enlargement in these regions. (C) 1997 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.