Effects of insulin and leptin in the ventral tegmental area and arcuate hypothalamic nucleus on food intake and brain reward function in female rats.
Effects of insulin and leptin in the ventral tegmental area and arcuate hypothalamic nucleus on food intake and brain reward function in female rats.
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DOI：
10.1016/j.bbr.2011.01.020
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发表时间：
2011-06-01
影响因子：
2.7
通讯作者：
Yamada, Hidetaka
中科院分区：
文献类型：
--
作者：
Bruijnzeel, Adrie W.;Corrie, Lu W.;Rogers, Jessica A.;Yamada, Hidetaka
有证据表明胰岛素和瘦素在食物摄入中的作用，但这些肥胖信号对大脑奖励系统的影响还不清楚。此外，胰岛素和瘦素对女性食物摄入量的影响也未得到充分研究。这些研究探讨了雌性大鼠腹侧被盖区（VTA）和下丘脑弓状核（Arc）胰岛素和瘦素对摄食和脑奖赏功能的作用。采用颅内自我刺激程序评价胰岛素和瘦素对奖赏系统的影响。大脑奖励阈值的升高指示大脑奖励功能的降低。双侧腹侧被盖区（15-500 ng/侧）或弧区（15-150 ng/侧）注射瘦素可减少摄食量72 h。将瘦素输注到VTA或Arc中导致输注后前48小时（VTA）或24小时（Arc）期间体重减轻。将胰岛素（0.005-5 mU/侧）注入VTA或Arc可减少24 h的摄食量，但不影响体重。双侧给予低剂量的瘦素（15 ng/侧）或胰岛素（0.005 mU/侧）至VTA升高脑奖励阈值。Arc中的胰岛素和瘦素都不影响大脑奖赏阈值。这些研究表明，腹侧被盖区瘦素或胰岛素水平的小幅增加会导致大脑奖赏功能的下降。腹侧被盖区或弧区胰岛素或瘦素水平相对较大的增加会减少食物摄入。
There is evidence for a role of insulin and leptin in food intake, but the effects of these adiposity signals on the brain reward system are not well understood. Furthermore, the effects of insulin and leptin on food intake in females are underinvestigated. These studies investigated the role of insulin and leptin in the ventral tegmental area (VTA) and the arcuate hypothalamic nucleus (Arc) on food intake and brain reward function in female rats. The intracranial self-stimulation procedure was used to assess the effects of insulin and leptin on the reward system. Elevations in brain reward thresholds are indicative of a decrease in brain reward function. The bilateral administration of leptin into the VTA (15–500 ng/side) or Arc (15–150 ng/side) decreased food intake for 72 h. The infusion of leptin into the VTA or Arc resulted in weight loss during the first 48 (VTA) or 24 h (Arc) after the infusions. The administration of insulin (0.005–5 mU/side) into the VTA or Arc decreased food intake for 24 h but did not affect body weights. The bilateral administration of low, but not high, doses of leptin (15 ng/side) or insulin (0.005 mU/side) into the VTA elevated brain reward thresholds. Neither insulin nor leptin in the Arc affected brain reward thresholds. These studies suggest that a small increase in leptin or insulin levels in the VTA leads to a decrease in brain reward function. A relatively large increase in insulin or leptin levels in the VTA or Arc decreases food intake.
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影响因子：
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