Reduced learning and memory performances in high-fat treated hamsters related to brain neurotensin receptor1 expression variations
Reduced learning and memory performances in high-fat treated hamsters related to brain neurotensin receptor1 expression variations
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DOI：
10.1016/j.bbr.2018.03.015
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发表时间：
2018-07-16
影响因子：
2.7
通讯作者：
Canonaco, Marcello
中科院分区：
文献类型：
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作者：
Fazzari, Gilda;Zizza, Merylin;Canonaco, Marcello
最近的迹象表明，高脂肪和富含糖的食物不仅会引起有害的生理条件，而且它们还会在控制认知和进食行为的大脑区域承受明显的结构变化。食物消耗加上神经元能量调节机制似乎构成了一个复杂的系统，确保食物卡路里不会超过人体所需。同时，下丘脑(HTH)、海马体(HIP)和杏仁核(AMY)等边缘喂食站的肥胖相关特性往往通过不同神经肽的相互作用来控制饮食习惯。为此，我们打算将一种关键的抗肥胖神经肽受体神经降压素1(NTR1)的表达差异与高脂饮食(HFD)下冬眠金黄地鼠(Mesocricus Auratus)的助记性能联系起来。有趣的是，从治疗的第五周到第十二周，这些仓鼠的体重显著增加(P<；0.01)，并伴随着血脂、胆固醇、甘油三酯和血糖水平的升高。与此同时，这些仓鼠的运动活动减少，如探索性比赛、饲养和梳理行为。更相关的是，他们在新奇物体识别(NOR)测试中无法识别新物体的能力非常极端(p<；0.001)，而且没有正确选择包含令人满意的奖励的条件位置偏好(Cpp)仪器的腔室。令人惊讶的是，HFD仓鼠的行为和记忆任务的改变与上述边缘部位NTR1表达的变化密切相关，从而表明这种神经系统极有可能成为治疗肥胖依赖性记忆功能障碍的替代方案。
Recent indications are suggesting that high fat and sugar-enriched foods do not only evoke harmful physiological conditions, but they also endure evident structural alterations in cerebral regions controlling cognitive and feeding behaviors. Food consumption plus neuronal energy regulatory mechanisms seem to constitute a complex system assuring that food calories do not exceed body requirements. At the same time obesogenic-related properties of limbic feeding stations like the hypothalamus (HTH), hippocampus (HIP) and amygdala (AMY) tend to control eating habits through the interaction of distinct neuropeptides. For this purpose, it was our intention to correlate expression differences of a key anti-obesogenic neuropeptide receptor i.e. neurotensin1 (NTR1) on mnemonic performances in the hibernating hamster (Mesocricetus auratus) exposed to a high fat diet (HFD). Interestingly, these hamsters exhibited a notable enhanced (p < 0.01) body weight from the fifth on to the twelfth week of treatment, which was accompanied by elevated blood lipid cholesterolo and triglycerides and glucose levels. At the same time these hamsters provided diminished locomotor activities such as exploratory bouts, rearing and grooming behaviors. Of greater relevance was their very extreme (p < 0.001) inability of identifying new objects during novel object recognition (NOR) tests along with not having correctly chosen the chamber of the conditioned place preference (CPP) apparatus, which contained the gratifying reward. Surprisingly the altered behavioral plus mnemonic tasks of HFD hamsters were tightly related to elevated NTR1 expression changes in the above limbic sites thus proposing this neuronal system as a highly probable alternative for treating obesity-dependent mnemonic dysfunctions.