BMD measurements of the spine derived from sagittal reformations of contrast-enhanced MDCT without dedicated software
BMD measurements of the spine derived from sagittal reformations of contrast-enhanced MDCT without dedicated software
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DOI：
10.1016/j.ejrad.2010.08.034
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发表时间：
2011-11-01
影响因子：
3.3
通讯作者：
Bauer, Jan S.
中科院分区：
文献类型：
--
作者：
Bauma, Thomas;Mueller, Dirk;Bauer, Jan S.
目的：用简单的PACS测量工具对常规腹部增强多层螺旋CT矢状面重建的腰椎进行QCT等效骨密度测量，并将该方法应用于MDCT数据集，以区分有无骨质疏松性椎体骨折的患者。材料和方法：8名绝经后妇女(65+/-5岁)接受标准QCT检查，评估L1-L3的骨密度。随后，对这些女性进行常规腹部增强多层螺旋CT扫描，采用矢状位重建测量L1-L3的表观骨密度。通过线性回归分析计算出骨密度的MDCT到QCT的转换方程。该转换方程被应用于75名绝经后妇女(66+/-4岁)的椎骨骨密度数据集(L1-L3)。75例患者中17例有骨质疏松性椎体骨折。结果：增强后的MDCT骨密度值平均比标准QCT高56 mg/ml。MDCT与标准QCT骨密度换算方程为BMDQCT=0.69×BMDCT-11 mg/ml，相关系数r=0.94(p<；0.05)，椎体骨折组换算BMD值明显低于非骨折组(69 mg/ml vs.85 mg/ml；p<；0.05)。使用ROC分析来区分有无椎体骨折的患者，换算的骨密度值得到AUC=0.72(p<；0.05)。矢状位重建骨密度测量的短期和长期可重复性误差分别为2.09%和7.70%。结论：常规腹部增强多层螺旋CT矢状位重建可以计算脊柱骨密度，所需技术和时间最少。使用转换方程，获得的骨密度数据可以区分有无骨质疏松性椎体骨折的患者。(C)2010爱思唯尔爱尔兰有限公司。保留所有权利。
Purpose: To assess QCT equivalent BMD of the lumbar spine in sagittal reformations of routine abdominal contrast-enhanced MDCT with simple PACS measurement tools and to apply this method to MDCT datasets for differentiating patients with and without osteoporotic vertebral fractures.Materials and methods: Eight postmenopausal women (65 +/- 5years) underwent standard QCT to assess BMD of L1-L3. Afterwards routine abdominal contrast-enhanced MDCT images of these women were obtained and apparent BMD of L1-L3 was measured using the sagittal reformations. The MDCT-to-QCT conversion equation for BMD was calculated with linear regression analysis. The conversion equation was applied to vertebral BMD datasets (L1-L3) of 75 postmenopausal women (66 +/- 4years). Seventeen of the 75 patients had osteoporotic vertebral fractures.Results: BMD values of contrast-enhanced MDCT were on average 56 mg/ml higher than those of standard QCT. A correlation coefficient of r = 0.94 (p < 0.05) was calculated for the BMD values of MDCT and standard QCT with the conversion equation BMDQCT = 0.69 x BMDMDCT - 11 mg/ml. Accordingly converted BMD values of patients with vertebral fractures were significantly lower than those of patients without vertebral fractures (69 mg/ml vs. 85 mg/ml; p < 0.05). Using ROC analysis to differentiate patients with and without vertebral fractures, AUC = 0.72 was obtained for converted BMD values (p < 0.05). Short- and long-term reproducibility errors for BMD measurements in the sagittal reformations amounted 2.09% and 7.70%, respectively.Conclusion: BMD measurements of the spine could be computed in sagittal reformations of routine abdominal contrast-enhanced MDCT with minimal technical and time effort. Using the conversion equation, the acquired BMD data could differentiate patients with and without osteoporotic vertebral fractures. (C) 2010 Elsevier Ireland Ltd. All rights reserved.