An Immunohistochemical Study of Thymic Epithelial Tumors: II. Lymphoid Component
An Immunohistochemical Study of Thymic Epithelial Tumors: II. Lymphoid Component
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胸腺上皮肿瘤的免疫组织化学研究：II。
DOI：
10.1097/00000478-198612000-00005
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Y. Shimosato
中科院分区：
文献类型：
--
作者：
Y. Sato;S. Watanabe;K. Mukai;T. Kodama;M. Upton;M. Goto;Y. Shimosato
本文应用一组单克隆和多克隆抗体，对9例胸腺瘤和1例胸腺鳞状细胞癌的淋巴细胞和组织细胞的组成和特性进行了免疫组化研究。9例胸腺瘤分为混合型7例，淋巴细胞型和上皮型各1例。包括两个转移性肿瘤和一个复发性肿瘤。几乎所有的淋巴细胞在混合型和淋巴细胞型的类别，无论是在原发部位或转移，是T淋巴细胞，显示出正常胸腺皮质的未成熟胸腺淋巴细胞表型。另一方面，一个上皮性胸腺瘤含有许多成熟的T淋巴细胞沿着未成熟的T细胞，与正常胸腺髓质一样。胸腺鳞癌浸润的T淋巴细胞均为成熟T淋巴细胞。这些结果表明，胸腺瘤的上皮细胞与共存的淋巴细胞有密切的关系，并保留正常胸腺上皮对应的功能特性。另一方面，胸腺上皮细胞的特异性功能在胸腺鳞状细胞癌中不再维持。
The cellular composition and characteristics of lymphocytes and histiocytes in nine cases of thymoma and one case of squamous cell carcinoma of the thymus were studied immunohistochemically, using a panel of monoclonal and polyclonal antibodies. Nine cases of thymoma were subclassified into seven cases of mixed type and one case each of predominantly lymphocytic type and predominantly epithelial type. Two metastatic tumors and one recurrent tumor were included. Almost all the lymphocytes in the mixed type and lymphocytic type categories, either in primary site or metastasis, were T lymphocytes which showed the immature thymic lymphocyte- phenotype of the normal thymic cortex. On the other hand, the one epithelial thymoma contained many mature T lymphocytes along with immature T cells, as in the normal thymic medulla. In thymic squamous cell carcinoma, all infiltrating T lymphocytes were mature T lymphocytes. These findings suggest that epithelial cells of thymomas have an intimate relationship with the coexisting lymphocytes and retain functional properties of the normal thymic epithelial counterpart. On the other hand, the specific function of thymic epithelial cells is no longer maintained in thymic squamous cell carcinoma.