Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea against Meloidogyne incognita
Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea against Meloidogyne incognita
复制标题
含硫脲和酰基硫脲的1,2,3-苯并三嗪-4-酮衍生物的合成及其对南方根结线虫的杀线虫活性
DOI：
10.1016/j.bmcl.2016.12.065
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发表时间：
2017
影响因子：
2.7
通讯作者：
Xu Xiaoyong
中科院分区：
文献类型：
--
作者：
Chang Yaning;Zhang Jingwei;Chen Xiulei;Li Zhong;Xu Xiaoyong
设计并合成了两个系列含硫脲和酰基硫脲的1，2，3-苯并三嗪-4-酮衍生物。生物活性测定结果表明，大部分化合物对线虫有较好的杀灭活性。在体内浓度为10.0 mg L-1。化合物A13、A17和B3在1.0 mg L-1浓度下对根结线虫二龄幼虫的抑制率分别为51.3%、58.3%和51.3%。含硫脲和酰基硫脲的1，2，3-苯并三嗪-4-酮衍生物的结构可进一步优化。
Two series of novel 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea were designed and synthesized. The bioassay results showed that most of the test compounds showed good nematicidal activity againstM. incognitaat the concentration of 10.0 mg L−1in vivo. The compoundsA13,A17andB3showed excellent nematicidal activity on the second stage juveniles of the root-knot nematode with the inhibition rate of 51.3%, 58.3% and 51.3% at the concentration of 1.0 mg L−1respectively. It suggested that the structure of 1,2,3-benzotriazin-4-one derivatives containing thiourea and acylthiourea could be optimized further.