Cerebral gray matter and white matter volume deficits in adolescent girls with anorexia nervosa
Cerebral gray matter and white matter volume deficits in adolescent girls with anorexia nervosa
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DOI：
10.1016/s0022-3476(96)70021-5
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发表时间：
1996-12-01
影响因子：
5.1
通讯作者：
Zipursky, RB
中科院分区：
文献类型：
--
作者：
Katzman, DK;Lambe, EK;Zipursky, RB
目的：本研究进行，以确定是否增加脑脊液（CSF）量发现神经性厌食症（AN）是在灰质或白色物质或both.Methods的差异的结果：13个青少年女孩与AN谁是接受住院治疗的三级保健大学儿童医院和8个健康女性对照组进行了研究，通过使用磁共振成像。通过开发的软件处理图像，将所有像素分类为CSF、灰质或白色物质。每个类的像素，然后在所有section.Results：AN组拉德较大的总CSF体积与赤字在总灰质和总白色物质的体积。报告的最低体重指数与胎儿脑脊液体积呈负相关，与总灰质体积呈正相关。尿游离皮质醇水平呈正相关，与总CSF容量呈负相关，与中央灰质volume.Conclusions：这些研究结果增加了支持认为，发现在AN的大脑异常在很大程度上是疾病的影响的结果。灰质和白色物质体积的这些差异在多大程度上是可逆的，恢复仍有待确定。
Objectives: This study was undertaken to determine whether the increased cerebrospinal fluid (CSF) volumes found in anorexia nervosa (AN) are the result of differences in gray matter or white matter volumes or both.Methods: Thirteen adolescent girls with AN who were receiving inpatient care at a tertiary-care university children's hospital and eight healthy female control subjects were studied by using magnetic resonance imaging. Images were processed by means of software developed to classify all pixels as either CSF, gray matter, or white matter. Pixels of each class were then summed across all sections.Results: The AN group Rad larger total CSF volumes in association with deficits in both total gray matter and total white matter volumes. Lowest reported body mass index was inversely correlated with fetal CSF volume and positively correlated with total gray matter volume. Urinary free cortisol levels were positively correlated with total CSF volume and inversely correlated with central gray matter volume.Conclusions: These findings add support to the view that the brain abnormalities found in AN are in large part the result of the effects of the illness. The extent to which these differences in gray matter and white matter volumes are reversible with recovery remains to be established.