Complexation of luteolin with lead (II): Spectroscopy characterization and theoretical researches.
Complexation of luteolin with lead (II): Spectroscopy characterization and theoretical researches.
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DOI：
10.1016/j.jinorgbio.2019.01.007
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发表时间：
2019-01
影响因子：
3.9
通讯作者：
Qian Wang;Lingling Zhao;Haoan Zhao;Xinyan Liu;Liguo Gao;N. Cheng;W. Cao
中科院分区：
文献类型：
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作者：
Qian Wang;Lingling Zhao;Haoan Zhao;Xinyan Liu;Liguo Gao;N. Cheng;W. Cao
研究了(CH3COO)2Pb·3H2O（三水合醋酸铅）与木犀草素、5,7,3',4'-四羟基黄酮在甲醇溶液中的相互作用。采用光谱（UV-Vis、FT-IR、HPLC-MS、1H NMR）和元素分析来评估木犀草素和 Pb(II) 的相互作用。结果表明，木犀草素通过两个木犀草素分子中4-羰基和5-羟基的螯合位点与Pb(II)发生反应。通过量子化学计算对配体和配合物的结构、能量、CDA（电荷分解分析）和轨道分析进行了分析，进一步证明木犀草素分子可以通过5-羟基-4-氧代螯合位点有效螯合Pb(II)。推测木犀草素未来很有潜力成为消除铅阳离子的保健品。
The interactions of (CH3COO)2Pb·3H2O (lead acetate trihydrate) with luteolin, 5,7,3′,4′-tetrahydroxyflavone, were investigated in methanol solution. The spectroscopy (UV–Vis, FT-IR, HPLC-MS,1H NMR) and elemental analysis were adopted to assess the interaction of luteolin and Pb(II). The results show that luteolin reacts with Pb(II) through the chelating sites of 4‑carbonyl and 5-hydroxy in two luteolin molecules. The structures, energies, CDA (charge decomposition analysis) and orbitals analysis of the ligand and complex have been analyzed according to quantum-chemical calculation, which is further proofed that luteolin molecule can effectively chelate Pb(II) by 5-hydroxyl-4-oxo chelating site. It is speculated that luteolin has a high potential of becoming a health care product to eliminate lead cation in the future.