Experimental measurement of the mechanical properties of carotid atherothrombotic plaque fibrous cap
Experimental measurement of the mechanical properties of carotid atherothrombotic plaque fibrous cap
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DOI：
10.1016/j.jbiomech.2009.04.025
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发表时间：
2009-08-07
影响因子：
2.4
通讯作者：
Gillard, J. H.
中科院分区：
文献类型：
--
作者：
Barrett, S. R. H.;Sutcliffe, M. P. F.;Gillard, J. H.
从患者中采集11个颈动脉粥样硬化血栓斑块样本。三个高度钙化的样本被丢弃，而八个得到了结果。材料的弹性性能进行了估计，通过拟合测得的压痕响应有限元模拟。该方法经过改进，并使用合成橡胶量化其准确性。新胡克形式的材料模型给出了一个很好的适合测量的组织响应。发现推断的剪切模量p在7-100 kPa的范围内，中值为11 kPa。对已发表材料数据的审查显示，人类动脉粥样硬化血栓组织的材料特性范围很广。在这些发表的结果中，强调了各向异性和时间依赖性的影响。目前的测量结果与Lee等人（1991）的静态径向压缩试验相当[来自人类动脉粥样硬化斑块的纤维帽的结构依赖性动态行为。Circulation 83，1764-1770]. (c)2009爱思唯尔有限公司保留所有权利。
Eleven carotid atherothrombotic plaque samples were harvested from patients. Three samples that were highly calcified were discarded, while eight yielded results. The elastic properties of the material were estimated by fitting the measured indentation response to finite element simulations. The methodology was refined and its accuracy quantified using a synthetic rubber. The neo-Hookean form of the material model gave a good fit to the measured response of the tissue. The inferred shear modulus p was found to be in the range 7-100 kPa, with a median value of 11 kPa. A review of published materials data showed a wide range of material properties for human atherothrombotic tissue. The effects of anisotropy and time dependency in these published results were highlighted. The present measurements were comparable to the static radial compression tests of Lee et al, 1991 [Structure-dependent dynamic behaviour of fibrous caps from human atherosclerotic plaques. Circulation 83, 1764-1770]. (c) 2009 Elsevier Ltd. All rights reserved.