Antimicrobial resistance of commensal Escherichia coli from dairy cattle associated with recent multi-resistant salmonellosis outbreaks
Antimicrobial resistance of commensal Escherichia coli from dairy cattle associated with recent multi-resistant salmonellosis outbreaks
复制标题
DOI：
10.1016/j.vetmic.2003.10.017
复制
发表时间：
2004-01-14
影响因子：
3.3
通讯作者：
Hancock, DD
中科院分区：
文献类型：
--
作者：
DeFrancesco, KA;Cobbold, RN;Hancock, DD
在家畜中使用抗菌药物被怀疑会导致细菌抗菌素耐药性 (AR) 的发展。将最近爆发涉及多重耐药 (MR) 沙门氏菌菌株的沙门氏菌病的奶牛场与对照农场的牛共生大肠杆菌分离株中的 AR 进行比较。对于大多数测试的抗菌药物，从受沙门氏菌病影响的农场中分离出的 AR 大肠杆菌百分比显着高于对照农场。来自病例农场和对照农场的小牛大肠杆菌的 AR 水平高于奶牛分离株。从案例农场和小牛中分离出的共生大肠杆菌往往更容易出现 MR。这些数据与最近爆发沙门氏菌病的农场存在较高的抗菌药物选择压力相一致，但这种关系的方向性仍有待阐明。在畜群和分子水平上更好地了解畜牧生产中 AR 细菌的流行病学对于减轻公共卫生和食品安全风险至关重要。 (C) 2003 Elsevier B.V. 保留所有权利。
The use of antimicrobial drugs in livestock is suspected to contribute to bacterial antimicrobial resistance (AR) development. Dairy farms experiencing recent outbreaks of salmonellosis involving multi-resistant (MR) Salmonella strains were compared to control farms with respect to AR among bovine commensal E. coli isolates. For most antimicrobials tested, the percentage of AR E. coli isolated from salmonellosis-affected farms was significantly higher than that from control farms. Calf E. coli from both case and control farms had greater levels of AR than cow isolates. Commensal E. coli isolates from case farms and calves tended to more frequently be MR. These data are consistent with the existence of higher antimicrobial selection pressure on farms with recent salmonellosis outbreaks, however, the directionality of the relationship remains to be elucidated. An improved understanding of the epidemiology of AR bacteria in livestock production, both at the herd and molecular level, is essential to mitigate risk to public health and food safety. (C) 2003 Elsevier B.V. All rights reserved.