Cowpox Virus Infection in Pet Rat Owners Not Always Immediately Recognized
Cowpox Virus Infection in Pet Rat Owners Not Always Immediately Recognized
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DOI：
10.3238/arztebl.2009.0329
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发表时间：
2009-05-08
影响因子：
7.7
通讯作者：
Nitsche, Andreas
中科院分区：
文献类型：
--
作者：
Becker, Christian;Kurth, Andreas;Nitsche, Andreas
背景：本文的目的是让所有专业的医生意识到人类牛痘感染的临床过程可能存在的差异。自从 2008 年春天在克雷菲尔德地区发现第一批白色宠物鼠主人感染牛痘病毒以来，这一问题一直引起人们的关注。2008 年 11 月，克雷菲尔德地区又出现了两起病例，此后德国和邻国的各个地区又收到了多起进一步的报告。 方法：作者报告了头六起记录在案的饲养宠物鼠的年轻人中感染牛痘病毒的病例，其中两起病例均为 典型和非典型临床过程。结果：所有6例病例的临床、分子生物学和血清学检查结果均证实牛痘病毒感染。所有患者的牛痘病毒血凝素基因的 DNA 序列都是相同的。这些感染是在与宠物鼠直接接触后发生的。结论：对本文所述病例的分子遗传学分析表明，在多个地理区域观察到的人类和宠物鼠中发生的牛痘病毒感染代表了尚未得到控制的单一流行病学事件。预计还会有更多病例。 Dtsch Arztebl Int 2009； 106(19): 329-34 DOI: 10.3238/arztebl.2009.0329
Background: The aim of this article is to make physicians of all specialties aware of the possible variations of clinical course in human cowpox infection. This has been a matter of current interest since the detection of a first cluster of infections among owners of white pet rats in the Krefeld area in the spring of 2008. Two further cases arose in the Krefeld area in November 2008, and there have since been multiple further reports from various regions in Germany and the neighboring countries.Method: The authors report on the first six documented cases of infection with cowpox virus among young persons owning pet rats, with both typical and atypical clinical courses.Results: The clinical, molecular biological, and serological findings confirmed cowpox virus infection in all six cases. The DNA sequence of the cowpox virus hemagglutinin gene was identical in all patients. The infections had arisen after direct contact with pet rats.Conclusions: Molecular genetic analysis of the cases described here suggests that the observed occurrence of cowpox virus infection among human beings and pet rats in multiple geographical areas represents a unitary epidemiological event that has not yet come under control. Further cases can be expected. Dtsch Arztebl Int 2009; 106(19): 329-34 DOI: 10.3238/arztebl.2009.0329