A programmed schedule of oocyte retrieval using mild ovarian stimulation (clomiphene citrate and recombinant follicle-stimulating hormone)
A programmed schedule of oocyte retrieval using mild ovarian stimulation (clomiphene citrate and recombinant follicle-stimulating hormone)
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DOI：
10.1007/s12522-011-0110-9
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发表时间：
2012-04-01
影响因子：
3.4
通讯作者：
Sugiyama, Rikikazu
中科院分区：
文献类型：
--
作者：
Nakagawa, Koji;Nishi, Yayoi;Sugiyama, Rikikazu
目的是建立一个温和的卵巢刺激方案，以帮助辅助生殖技术（ART）单位避免安排在周末，该方案指导患者在月经周期的第3 - 7天服用50 mg/天的克罗米芬：第3、5和7天给予225 IU的重组卵泡刺激素（rec-FSH）;在第9天施用人绒毛膜促性腺激素（hCG）;并且计划在第11天取卵（OPU）。从2008年10月到2009年10月，514名妇女在杉山诊所接受了轻度刺激的ART治疗，我们评估了OPU是否在计划的当天完成。在所有治疗周期中，419名（81.5%）在第11天（计划组）接受了OPU。在83个周期中需要额外的rec-FSH给药，在这种情况下，在第12天或更晚进行OPU。在12个周期内，OPU被取消。计划外组（n = 95）包括延迟OPU周期和取消周期。在所有治疗周期中，计划组和非计划组分别有332个周期和68个周期接受了胚胎移植，分别有81个和16个周期妊娠。使用该方案，约80%的周期在计划日进行OPU。大多数OPU的周末安排可以避免使用这种温和的刺激。
The purpose was to establish a mild ovarian stimulation protocol that would help assisted reproductive technology (ART) units to avoid scheduling on weekends.This protocol directed patients to take 50 mg/day of clomiphene citrate between days 3 and 7 of the menstrual cycle: 225 IU of recombinant follicle-stimulating hormone (rec-FSH) were administered on days 3, 5 and 7; human chorionic gonadotropin (hCG) was administered on day 9; and, oocyte pick-up (OPU) was planned for day 11. From October 2008 through October 2009, 514 women underwent ART treatment with mild stimulation at the Sugiyama Clinic, and we evaluated whether OPU was accomplished on the planned day.Of all the treatment cycles, 419 (81.5%) underwent OPU on day 11 (scheduled group). Additional rec-FSH administration was needed in 83 cycles, in which case OPU was performed on day 12 or later. In 12 cycles, OPU was canceled. The unscheduled group (n = 95) consisted of delayed OPU cycles and canceled cycles. Of all treatment cycles, 332 cycles in the scheduled group and 68 cycles in the unscheduled group underwent embryo transfer, with 81 and 16, respectively, resulting in pregnancies.Using this protocol, OPU was performed on the scheduled day in about 80% of the cycles. Most weekend scheduling of OPU can be avoided using this mild stimulation.