Linkage of dermatomyositis in the Shetland Sheepdog to chromosome 35
Linkage of dermatomyositis in the Shetland Sheepdog to chromosome 35
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DOI：
10.1111/j.1365-3164.2005.00469.x
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发表时间：
2005-12-01
影响因子：
1.4
通讯作者：
Rees, CA
中科院分区：
文献类型：
--
作者：
Clark, LA;Credille, KM;Rees, CA
皮肌炎是一种皮肤和肌肉的炎症性疾病，最常见于设得兰群岛牧羊犬。皮肌炎的临床表现和发病年龄差异很大，并且在临床症状出现之前无法诊断皮肌炎使得疾病难以控制。鉴定与皮肌炎共分离的遗传标记将有助于发展基于DNA的检测，用于早期检测受影响的狗。我们报告使用连锁不平衡（LD）定位，以确定连锁表型皮肌炎的设得兰群岛牧羊犬。犬35号染色体上的微卫星标记FH3570有LD的证据（P = 0.00002）。进一步的研究是必要的，以缩小区域窝藏皮肌炎位点，确定候选基因和确定遗传方式。
Dermatomyositis is an inflammatory disease of the skin and muscle and is most commonly found in the Shetland sheepdog. Both the clinical presentation and the age of onset of dermatomyositis vary widely, and the inability to diagnose dermatomyositis before clinical symptoms ensue has made control of the disease difficult. Identification of a genetic marker that cosegregates with dermatomyositis would facilitate the development of a DNA-based test for the early detection of affected dogs. We report the use of linkage disequilibrium (LD) mapping to identify linkage to phenotypic dermatomyositis in the Shetland sheepdog. One marker, microsatellite marker FH3570 on canine chromosome 35, had evidence of LD (P = 0.00002). Further studies are necessary to narrow the region harbouring the dermatomyositis locus, identify candidate genes and determine mode of inheritance.