Aberrant Maturation of the Uncinate Fasciculus Follows Exposure to Unpredictable Patterns of Maternal Signals
Aberrant Maturation of the Uncinate Fasciculus Follows Exposure to Unpredictable Patterns of Maternal Signals
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DOI：
10.1523/jneurosci.0374-20.2020
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发表时间：
2021-02-10
影响因子：
5.3
通讯作者：
Davis, Elysia Poggi
中科院分区：
文献类型：
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作者：
Granger, Steven J.;Glynn, Laura M.;Davis, Elysia Poggi
在各个物种中，不可预测的母性行为模式正在成为日后生活中异常认知和情感结果的新预测因素。在动物模型中，暴露于不可预测的母性行为模式会改变大脑回路的成熟以及认知和情感结果。然而，人类暴露于这些信号是否会改变大脑通路的发育尚不清楚。在母子二人组中，我们检验了婴儿期暴露于更多不可预测的母体信号与皮质边缘通路异常成熟相关的假设。我们集中在钩束，初级纤维束连接杏仁核的眶额皮质和内侧颞叶-前额叶皮层电路的关键组成部分。在6个月和12个月时评估婴儿暴露于不可预测的母体感觉信号。使用高角分辨率扩散成像，我们量化的钩束的完整性，使用广义分数各向异性（GFA）。婴儿期母亲的不可预测性较高预示着9-11岁儿童的钩束GFA较大（n = 69，29名女性）。与钩突相反，第二个皮质边缘投射，海马扣带的GFA与母体的不可预测性无关。解决钩和扣带关系的整体功能意义，我们发现，由此产生的内侧颞叶-前额叶皮层连接的不平衡部分介导了不可预测的母体感觉信号和情节记忆功能受损之间的关联。这些结果表明，皮质边缘回路的不平衡成熟是一种机制，早期不可预测的感觉信号可能会影响以后的生活认知。
Across species, unpredictable patterns of maternal behavior are emerging as novel predictors of aberrant cognitive and emotional outcomes later in life. In animal models, exposure to unpredictable patterns of maternal behavior alters brain circuit maturation and cognitive and emotional outcomes. However, whether exposure to such signals in humans alters the development of brain pathways is unknown. In mother-child dyads, we tested the hypothesis that exposure to more unpredictable maternal signals in infancy is associated with aberrant maturation of corticolimbic pathways. We focused on the uncinate fasciculus, the primary fiber bundle connecting the amygdala to the orbitofrontal cortex and a key component of the medial temporal lobe-prefrontal cortex circuit. Infant exposure to unpredictable maternal sensory signals was assessed at 6 and 12 months. Using high angular resolution diffusion imaging, we quantified the integrity of the uncinate fasciculus using generalized fractional anisotropy (GFA). Higher maternal unpredictability during infancy presaged greater uncinate fasciculus GFA in children 9-11 years of age (n = 69, 29 female). In contrast to the uncinate, GFA of a second corticolimbic projection, the hippocampal cingulum, was not associated with maternal unpredictability. Addressing the overall functional significance of the uncinate and cingulum relationships, we found that the resulting imbalance of medial temporal lobe-prefrontal cortex connectivity partially mediated the association between unpredictable maternal sensory signals and impaired episodic memory function. These results suggest that unbalanced maturation of corticolimbic circuits is a mechanism by which early unpredictable sensory signals may impact cognition later in life.