Simulation of blast lung injury induced by shock waves of five distances based on finite element modeling of a three-dimensional rat
Simulation of blast lung injury induced by shock waves of five distances based on finite element modeling of a three-dimensional rat
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基于三维大鼠有限元建模的五距离冲击波致爆炸性肺损伤模拟
DOI：
10.1038/s41598-019-40176-7
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发表时间：
2019-03-05
影响因子：
4.6
通讯作者：
Chai Jia-ke
中科院分区：
文献类型：
--
作者：
Chang Yang;Zhang Dong-hai;Chai Jia-ke
军用和民用爆炸伤所致的冲击波肺损伤(BLI)已成为造成冲击伤患者死亡的主要原因。通过建立大鼠爆炸区域的三维(3D)模型，模拟皮肤和肺的表面压力。从爆震中心到大鼠爆心的5个距离处进行压力分布。当距离分别为40 cm、50 cm、60 cm、70 cm和80 cm时，体表最大压力分别为634.77、362.46、248.11、182.13和109.29 kPa.体表压力范围分别为928~2916 、733~254 、488~1236 、357~1189 和314~992 Pa.在每个肺叶模型表面设置6个虚拟点后，进行模拟压力测量和相应的病理解剖，以验证建模的准确性。对于双肺，当距离分别为40 cm、50 cm和60 cm时，皮尔逊值具有很强的相关性。当距离为70 cm和80 cm时，皮尔逊值呈弱线性相关。这种计算机模拟提供了动态解剖以及功能和生物力学信息。
Blast lung injury (BLI) caused by both military and civilian explosions has become the main cause of death for blast injury patients. By building three-dimensional (3D) models of rat explosion regions, we simulated the surface pressure of the skin and lung. The pressure distributions were performed at 5 distances from the detonation center to the center of the rat. When the distances were 40 cm, 50 cm, 60 cm, 70 cm and 80 cm, the maximum pressure of the body surface were 634.77kPa, 362.46kPa, 248.11kPa, 182.13kPa and 109.29kPa and the surfaces lung pressure ranges were 928–2916 Pa, 733–2254 Pa, 488–1236 Pa, 357–1189 Pa and 314–992 Pa. After setting 6 virtual points placed on the surface of each lung lobe model, simulated pressure measurement and corresponding pathological autopsies were then conducted to validate the accuracy of the modeling. For the both sides of the lung, when the distance were 40 cm, 50 cm and 60 cm, the Pearson’s values showed strong correlations. When the distances were 70 cm and 80 cm, the Pearson’s values showed weak linear correlations. This computational simulation provided dynamic anatomy as well as functional and biomechanical information.