Inhibition of Moisture Penetration to the Skin by a Novel Incontinence Barrier Product
Inhibition of Moisture Penetration to the Skin by a Novel Incontinence Barrier Product
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新型失禁屏障产品抑制水分渗透到皮肤
DOI：
10.1016/s1071-5754(98)90081-x
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
J. Proch
中科院分区：
文献类型：
--
作者：
J. Vinson;J. Proch
目的：与目前市场上可获得的产品(Peri-Care；Sweet Corp.和Double-Guard；设计：以规定的时间间隔测量皮肤中的染料浸出量，并用分光光度法测量染料的量。背景和对象：两组皮肤白皙的志愿者，6名年龄在22岁至31岁的年轻人和6名年龄在61岁至73岁的老年志愿者。仪器：Spectronic601分光光度计。方法：将刻在前臂腹侧皮肤上的矩形(1英寸x 4英寸)分成4 1英寸x 1英寸的正方形，在上面涂上50[亩]L不同的屏障产品。将浸透了70[亩]L的FD&C红色染料40号溶液的创可贴(强生)涂在处理过的方块上，并在规定的时间间隔内放置长达8小时。结果：除老年组1个时间点外，该多屏障产品对示踪剂进入皮肤的抑制作用明显优于其他2个产品。结论：非侵入性临床前方法显示，该原型屏障霜可抑制模拟尿液密度和离子强度的溶液在皮肤上的吸收。阐明了这些方法的优点和局限性，并提出了临床研究的方向。
Objective: To measure the ability of a multiple-barrier product to inhibit the passage of a highly water-soluble tracer into the skin when compared with products currently available on the market (Peri-Care; Sween Corp., and Double-Guard; CR Bard, Inc.)Design: Dye extraction from the skin was measured at specified intervals and a spectrophotometric measurement of the amount of dye was obtained.Setting and Subjects: Two groups of light-skinned volunteers, 6 young adults subjects, aged 22 to 31 years, and 6 older subjects, aged 61 to 73 years, were studied in a controlled laboratory setting.Instruments: Spectronic 601 spectrophotometer.Methods: Rectangles (1 inch x 4 inch), inscribed on the ventral forearm skin, were divided into 4 1 inch x 1-inch squares, onto which 50 [mu] L of different barrier products were spread. Band-Aids (Johnson & Johnson), saturated with 70 [mu] L of an FD&C red dye No. 40 solution, were placed over the treated squares and left in place for specified intervals up to 8 hours. Similarly treated Band-Aids placed onto untreated skin comprised the controls.Main Outcome Measure: Amount of dye extracted from the skin as reflected by absorbance spectrophotometry.Results: This multiple-barrier product inhibited the passage of the tracer into the skin significantly better than the other 2 products at all time points, except for 1 point in the elderly group.Conclusion: Noninvasive preclinical methods show that this prototype barrier cream inhibits the absorption onto the skin of a solution simulating the density and ionic strength of urine. The advantages and limitations of the methods are clarified and directions for clinical research are suggested.