TAMable tumor-associated macrophages in response to innate RNA sensing.

TAMable tumor-associated macrophages in response to innate RNA sensing.
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DOI:
10.4161/onci.19894
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发表时间:
2012-09-01
期刊:
影响因子:
7.2
通讯作者:
Matsumoto M
Matsumoto M
中科院分区:
医学2区
文献类型:
--
作者:
Seya T;Shime H;Matsumoto M

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Antitumor effect of PolyI:C (a viral dsRNA analog) has been attributed to dendritic cell (DC)-maturation activity, that drives antitumor NK cells, DC cross-presentation, cytotoxic T lymphocytes and many IFN-inducible genes. According to a recent paper, tumor-infiltrating M2 macrophages are found to become an additional antitumor effector through polyI:C response.
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