Objective assessment of terbinafine-induced taste loss.
Objective assessment of terbinafine-induced taste loss.
复制标题
客观评估特比萘芬引起的味觉丧失。
DOI：
10.1097/01.mlg.0000181462.08683.0c
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Haxel,BorisR
中科院分区：
文献类型：
--
作者：
Doty,RichardL;Haxel,BorisR
目的：特比萘芬（Lamisil）是一种广泛使用的口服抗真菌药物，据报道，0.6%至2.8%的服用者会导致味觉丧失。然而，许多所谓的味觉问题反映了嗅觉问题，并且基于对单个受试者的全口测试发表的关于该主题的唯一实证研究没有发现特比萘芬相关的缺陷。在这项研究中，我们定量评估，使用验证良好的味觉和嗅觉测试，化学感觉功能在特比萘芬治疗后抱怨味觉障碍的6名患者，并将他们的测试分数与6名年龄，种族和性别匹配的正常controls.Methods：味觉功能测量使用96试验区域测试，评估甜，酸，苦，咸的味觉感知在前（颅神经[CN] VII）和后（CN IX）舌味蕾领域。使用宾夕法尼亚大学的40项味觉识别测试对双侧味觉功能进行评估。结果：在舌前部和舌后部区域，甜味、酸味和苦味刺激的味觉功能均显著降低。对于氯化钠，减量仅限于后部区域。嗅觉功能在正常范围内。结论：这些研究结果1）支持轶事病例报告的味道损失后特比萘芬使用，2）证明，所有四个主要的味道品质受到影响，和3）表明，嗅觉功能障碍是不参与。由于自我报告明显低估了化学感觉缺陷，对接受特比萘芬的患者进行更广泛的定量测试可能会发现特比萘芬诱导的味觉丧失的患病率比目前报道的要高得多。由于年龄超过65岁和体重指数较低是特比萘芬引起味觉丧失的风险因素，因此医生应特别警惕服用这种药物的老年人，他们可能会因味觉下降而变得抑郁或改变食物摄入量。
Objectives:Terbinafine (Lamisil), a widely prescribed oral antifungal agent, reportedly induces taste loss in 0.6% to 2.8% of those taking the drug. However, many so‐called taste problems reflect olfactory problems, and the sole empirical study published on this topic, based on whole‐mouth testing of a single subject, found no terbinafine‐related deficit. In this study, we quantitatively assessed, using well‐validated taste and smell tests, chemosensory function in six patients complaining of taste disturbance after terbinafine treatment and compared their test scores to those of six age‐, race‐, and sex‐matched normal controls.Methods:Taste function was measured using a 96‐trial regional test that assesses sweet, sour, bitter, and salty taste perception within the anterior (cranial nerve [CN] VII) and posterior (CN IX) lingual taste bud fields. Smell function was bilaterally evaluated using the 40‐item University of Pennsylvania Smell Identification Test.Results:Taste function for sweet‐, sour‐, and bitter‐tasting stimuli was significantly depressed in both the anterior and posterior lingual regions. For sodium chloride, the decrements were confined to the posterior region. Olfactory function was within normal limits.Conclusion:These findings 1) support anecdotal case reports of taste loss after terbinafine use, 2) demonstrate that all four major taste qualities are affected, and 3) suggest that olfactory dysfunction is not involved. Because self‐report markedly underestimates chemosensory deficits, more extensive quantitative testing of patients receiving terbinafine will likely reveal a much higher prevalence of terbinafine‐induced taste loss than currently reported. Since being older than 65 years of age and having a low body mass index are reportedly risk factors for terbinafine‐induced taste loss, physicians should be particularly on the alert for elderly persons taking this medication who may become depressed or alter their food intake in response to decreased taste sensation.