EphA receptor signaling--complexity and emerging themes.

EphA receptor signaling--complexity and emerging themes.
复制标题

DOI:
10.1016/j.semcdb.2011.10.013
复制
发表时间:
2012-02
影响因子:
7.3
通讯作者:
Wang, Bingcheng
Wang, Bingcheng
中科院分区:
生物学2区
文献类型:
--
作者:
Miao, Hui;Wang, Bingcheng

文献摘要

参考文献

被引文献

相似文献

Eph和ephrin信号传导对细胞行为的影响是复杂的并且高度依赖于环境。由Eph受体激活启动的正向信号传导和由ephrin激活启动的反向信号传导通常介导相反的作用。最近认识到Eph受体的明显的不依赖配体的功能增加了另一层复杂性。本文就近年来Eph受体A亚家族和ephrin配体信号转导的研究进展作一综述。我们将专注于EphA/ephrin-A信号在几个生理和疾病过程的背景下,其中最近取得了新的进展,统一的主题正在出现在以前的混乱。对于更全面的调查文献Eph/ephrin信号通路和网络,读者被称为优秀的评论都在这卷和其他最近的出版物。
The impact of Eph and ephrin signaling on cell behavior is complex and highly context dependent. Forward signaling initiated by Eph receptor activation and reverse signaling initiated by ephrin activation often mediate opposite effects. The apparent ligand-independent functions of Eph receptors recognized recently add another layer of complexity. This review will attempt to sort out the information generated recently on signaling by the A subfamily of Eph receptors and ephrin ligands. We will focus on EphA/ephrin-A signaling in the context of several physiological and disease processes, where new progresses have been made lately and unifying themes are emerging amid previous confusions. For more comprehensive survey of literature on Eph/ephrin signaling pathways and networks, readers are referred to outstanding reviews both in this volume and in other recent publications.
连接相关的蛋白AF-6在大脑中细胞细胞接触的专用部位与特定的EPH受体酪氨酸激酶相互作用。
DOI: 10.1083/jcb.144.2.361
发表时间: 1999-01-25
影响因子: 7.8
作者:
Buchert, M;Schneider, S;Meskenaite, V;Adams, M T;Canaani, E;Baechi, T;Moelling, K;Hovens, C M
通讯作者: Hovens, C M
DOI: 10.1016/j.devcel.2009.08.009
发表时间: 2009-10-20
期刊: DEVELOPMENTAL CELL
影响因子: 11.8
作者:
Brisbin, Sarah;Liu, Jun;Chin-Sang, Ian
通讯作者: Chin-Sang, Ian
DOI: 10.1182/blood-2004-08-2981
发表时间: 2005-04-01
期刊: BLOOD
影响因子: 20.3
作者:
Aasheim, HC;Delabie, J;Finne, EF
通讯作者: Finne, EF
DOI: 10.1016/s0006-8993(99)01112-9
发表时间: 1999-03-06
期刊: BRAIN RESEARCH
影响因子: 2.9
作者:
Bruce, V;Olivieri, G;Miescher, GC
通讯作者: Miescher, GC
DOI: 10.1172/jci33154
发表时间: 2008-01-01
影响因子: 15.9
作者:
Brantley-Sieders, Dana M.;Zhuang, Guanglei;Chen, Jin
通讯作者: Chen, Jin