INFECTIVITE ET PROPRIETE HEMAGGLUTINANTE DU VIRUS INFLUENZA TRAITE A DIFFERENTS PH
INFECTIVITE ET PROPRIETE HEMAGGLUTINANTE DU VIRUS INFLUENZA TRAITE A DIFFERENTS PH
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DOI：
10.1139/m65-114
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发表时间：
1965-01-01
影响因子：
2.8
通讯作者：
BOUDREAULT, A
中科院分区：
文献类型：
--
作者：
CHAGNON, A;GILKER, JC;BOUDREAULT, A
在37℃、不同pH值处理4小时后，对流感病毒的传染性和血凝效价进行了研究。由于B型流感病毒株比A型流感病毒株更不稳定，因此在每种类型中，流感病毒的传染性损失是不同的。此外，很明显，马流感病毒比人流感病毒株更耐酸。与其传染性相比，酸性pH更容易改变流感病毒的血凝活性。这些实验表明，首先是表面蛋白质复合体的快速破坏，然后是核蛋白较慢的变性。
The infectivity and hemagglutination titers of influenza viruses were studied after treatment at different pH values during 4 hours at 37[degree]C. Influenza viruses appeared to be acid-labile. The loss of infectivity of influenza viruses varied within each type, since strains of type B were more labile than those of type A. Moreover, it appeared clearly that equine influenza virus is more resistant to acid than human strains. The acid pH alters more readily the hemagglutinating activity of influenza virus than its infectivity. These experiments would imply that at first there is a rapid destruction of surface protein complexes followed by a less rapid denaturation of nucleoproteins.