The formation of bone under the influence of epithelium of the urinary tract
The formation of bone under the influence of epithelium of the urinary tract
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DOI：
10.1001/archsurg.1931.01160030026002
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发表时间：
1931-03-01
影响因子：
--
通讯作者：
Huggins, CB
中科院分区：
文献类型：
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作者：
Huggins, CB
在狗、兔和人的泌尿道中骨的异常发生已经被认识到，但尚未完全理解。在狗中，将结缔组织移植到膀胱并将输尿管移植到皮肤（从而消除了尿液作为骨化的可能原因），导致膀胱筋膜移植物中不断形成骨。骨形成于上皮下的结缔组织中，仅在移植筋膜中形成，而从不在膀胱的肌肉壁中形成。将膀胱粘膜移植到躯干和四肢的筋膜层、皮下组织和横纹肌，会形成上皮衬里的囊肿，其中含有高磷和钙含量以及低pH值的液体，部分被骨骼包围。骨位于结缔组织中，不与粘膜直接接触。它是真正的膜骨，有营养管和造血骨髓。如果移植物存活，这种骨在第18天后不断出现在狗体内。肾、脾、腹膜和膀胱肌壁在受到膀胱上皮生长的影响时不会骨化。胃、空肠、胆囊和结肠上皮在移植到壁筋膜中不形成骨。输尿管和肾盂上皮的作用方式与膀胱上皮相同。将膀胱上皮移植到兔或白化病大鼠的壁筋膜中不会导致骨沉积。
The abnormal occurrence of bone in the urinary tract of the dog, rabbit and man has been recognized but incompletely understood. In dogs transplantation of connective tissue to the urinary bladder with transplantation of the ureters to the skin (thus eliminating urine as a possible cause of ossification) resulted constantly in the formation of bone in the fascia transplant in the bladder. The bone forms in the connective tissue underneath the epithelium only in the transplanted fascia, never in the muscular wall of the bladder. Transplantation of urinary bladder mucosa to the fascial sheets, subcutaneous tissue and striated muscle of the trunk and extremities results in the formation of an epithelium-lined cyst containing fluid with a high P and Ca content and a low pH, that is partially surrounded by bone. The bone is in the connective tissue, not in direct contact with the mucous membrane. It is true membrane bone with nutrient canals and hemopoietic marrow. This bone occurs in the dog constantly after the 18th day, provided the transplant survives. The kidney, spleen, peritoneum and bladder muscle wall do not ossify when exposed to the influence of the growing urinary bladder epithelium. The gastric, jejunal, gall bladder, and colic epithelia do not form bone in transplants to the parietal fascia. The ureteral and renal pelvis epithelia act in the same way as the bladder epithelium. Transplantation of the bladder epithelium to the parietal fascias in the rabbit or albino rat does not result in the deposition of bone.