Adding Meaning to Memories: How Parietal Cortex Combines Semantic Content with Episodic Experience.
Adding Meaning to Memories: How Parietal Cortex Combines Semantic Content with Episodic Experience.
复制标题
在记忆中增加含义：顶叶皮质如何将语义内容与情节体验结合在一起。
DOI：
10.1523/jneurosci.1919-22.2023
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发表时间：
2023-09-20
影响因子：
5.3
通讯作者：
Kuhl, Brice A.
中科院分区：
文献类型：
--
作者：
Lee, Hongmi;Keene, Paul A.;Sweigart, Sarah C.;Hutchinson, Benjamin;Kuhl, Brice A.
人类记忆的神经影像学研究一直发现顶叶皮层的单变量反应跟踪刺激的情景体验（无论刺激是“旧”还是“新”）。最近，基于模式的功能磁共振成像研究表明，顶叶皮层也携带有关记忆经验的语义内容的信息。然而，目前还没有很好地理解如何记忆为基础的和内容为基础的信号整合在顶叶皮层。在这里，在人类（男性和女性）中，我们使用体素编码模型和识别记忆任务来预测复杂自然场景图像诱发的fMRI活动模式，基于（1）情节历史和（2）每个图像的语义内容。模型生成和比较不同的子区域顶叶皮层和枕颞叶皮层。我们发现，顶叶和枕颞区每个编码的记忆和内容的信息，但他们的不同之处在于他们如何联合收割机这些信息。在顶叶亚区，角回的特点是强大的和重叠的记忆和内容的影响。此外，主题特定的语义调谐功能表明，成功的再认转移角回的调谐功能的幅度，但不改变调谐的选择性。换句话说，记忆和内容的影响是加性的角回。这种数据模式与枕颞叶皮层形成对比，枕颞叶皮层的记忆和内容效应是相互作用的：记忆效应优先由调整到记忆图像内容的体素来表达。总的来说，这些发现提供了独特的见解顶叶皮层如何结合有关情节记忆和语义内容的信息。人类记忆的神经成像研究已经确定了多个大脑区域，这些区域不仅携带关于视觉刺激“是否”被成功识别的信息，而且还携带该刺激的内容包括“什么”的信息。然而，一个基本的和开放的问题是大脑如何整合这两种类型的信息（记忆和内容）。在这里，使用功能磁共振成像分析方法的强大组合，我们表明，顶叶皮层，特别是角回，强大地结合记忆和内容相关的信息，但这两种形式的信息是通过添加剂，独立的信号表示。相反，高级视觉皮层的记忆效应严重依赖于内容表征（并与内容表征相互作用）。总之，这些发现揭示了大脑结合记忆和内容相关信息的多种不同方式。
Neuroimaging studies of human memory have consistently found that univariate responses in parietal cortex track episodic experience with stimuli (whether stimuli are 'old' or 'new'). More recently, pattern-based fMRI studies have shown that parietal cortex also carries information about the semantic content of remembered experiences. However, it is not well understood how memory-based and content-based signals are integrated within parietal cortex. Here, in humans (males and females), we used voxel-wise encoding models and a recognition memory task to predict the fMRI activity patterns evoked by complex natural scene images based on (1) the episodic history and (2) the semantic content of each image. Models were generated and compared across distinct subregions of parietal cortex and for occipitotemporal cortex. We show that parietal and occipitotemporal regions each encode memory and content information, but they differ in how they combine this information. Among parietal subregions, angular gyrus was characterized by robust and overlapping effects of memory and content. Moreover, subject-specific semantic tuning functions revealed that successful recognition shifted the amplitude of tuning functions in angular gyrus but did not change the selectivity of tuning. In other words, effects of memory and content were additive in angular gyrus. This pattern of data contrasted with occipitotemporal cortex where memory and content effects were interactive: memory effects were preferentially expressed by voxels tuned to the content of a remembered image. Collectively, these findings provide unique insight into how parietal cortex combines information about episodic memory and semantic content. SIGNIFICANCE STATEMENT Neuroimaging studies of human memory have identified multiple brain regions that not only carry information about “whether” a visual stimulus is successfully recognized but also “what” the content of that stimulus includes. However, a fundamental and open question concerns how the brain integrates these two types of information (memory and content). Here, using a powerful combination of fMRI analysis methods, we show that parietal cortex, particularly the angular gyrus, robustly combines memory- and content-related information, but these two forms of information are represented via additive, independent signals. In contrast, memory effects in high-level visual cortex critically depend on (and interact with) content representations. Together, these findings reveal multiple and distinct ways in which the brain combines memory- and content-related information.