A case-control study on Alzheimer's disease and exposure to anesthesia
A case-control study on Alzheimer's disease and exposure to anesthesia
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DOI：
10.1007/s100720200017
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发表时间：
2002-04-01
影响因子：
3.3
通讯作者：
Lenzi, GL
中科院分区：
文献类型：
--
作者：
Gasparini, M;Vanacore, N;Lenzi, GL
进行了一项以医院为基础的回顾性病例对照研究，旨在评价麻醉暴露与阿尔茨海默病（AD）之间的关联。共115例AD患者。研究了230例帕金森病（PD）患者和230例非退行性神经系统疾病患者。每例AD病例的性别、年龄（3岁）和居住的地理区域与4例对照（2例PD患者和2例其他神经系统疾病）相匹配。通过医院记录收集关于全身麻醉暴露和其他变量的信息。AD的风险与发病前1年和5年的麻醉暴露之间没有相关性，AD的风险与手术次数之间也没有相关性。一个显着的差异之间观察到的平均年龄的AD患者和对照组接受外科手术。本研究揭示了全身麻醉暴露与AD之间缺乏相关性。需要进行前瞻性流行病学研究，以调查麻醉暴露水平，以及麻醉暴露与遗传因素（如APOE ε 4基因型）之间的任何可能关系。
A retrospective hospital-based case-control study was performed with the aim to evaluate the association between exposure to anesthesia and Alzheimer's disease (AD). A total of 115 AD patients. 230 Parkinson's disease (PD) patients and 230 patients with non-degenerative neurological disease were studied. Each AD case was matched for sex, age ( 3 years) and geographic area of residence with four controls (2 PD patients and 2 with other neurological disease). Information about exposure to general anesthesia and other variables was gathered through hospital records. No associations were found between the risk of AD and the exposure to anesthesia in the I and 5 years preceding disease onset, nor between the risk of AD and the number of surgical operations. A significant difference was observed between the mean age of AD patients and controls undergoing surgical procedures. The present study reveals a lack of association between exposure to general anesthesia and AD. Prospective epidemiological studies are needed in order to investigate levels of exposure to anesthesia, as well as any possible relationships between anesthetic exposure and genetic factors (e.g. APOEepsilon4 genotype).