Association between fecal microbiota and generalized anxiety disorder: Severity and early treatment response
Association between fecal microbiota and generalized anxiety disorder: Severity and early treatment response
复制标题
粪便微生物群与广泛性焦虑症之间的关联：严重程度和早期治疗反应
DOI：
10.1016/j.jad.2019.08.014
复制
发表时间：
2019-12-01
影响因子：
6.6
通讯作者：
Peng Zheng-wu
中科院分区：
文献类型：
--
作者：
Chen Yi-huan;Bai Jie;Peng Zheng-wu
背景：异常肠道微生物组组成与焦虑样行为之间的关联已经得到了很好的建立。然而，目前尚不清楚肠道微生物组的组成是否与广泛性焦虑症（GAD）的严重程度和缓解临床症状的patient.Methods：粪便样本36例活动性GAD（A-GAD组）和24匹配的健康对照组（HC组）进行了分析，通过16 S rRNA基因测序。焦虑与汉密尔顿焦虑量表和自评焦虑量表进行了评估，并在基线和1个月后的药物treatment.Results：肠道微生物组组成的功能进行了全面评估在A-GAD患者，较少的操作分类单位和较低的粪便细菌α多样性。具体而言，厚壁菌门和Tenericutes丰度较低的A-GAD患者，和几个属的A-GAD和HC组中的差异。粪前列腺素类真杆菌、瘤胃球菌UCG-014和普雷沃菌9的丰度与焦虑程度呈负相关，与焦虑减轻呈正相关;拟杆菌和土志贺菌的丰度与焦虑程度呈正相关。性别、吸烟和饮酒影响肠道微生物组组成。局限性：样本量较小，仅在基线时收集粪便样本;因此，肠道植物群变化与疾病缓解之间的因果关系尚未建立。此外，不同药物对肠道微生物组成的影响没有调查。结论：改变肠道微生物组成可能有助于GAD的发病和缓解。
Background: Associations between abnormal gut microbiome compositions and anxiety-like behaviors are well established. However, it is unknown whether the gut microbiome composition is associated with the severity of generalized anxiety disorder (GAD) and relief from clinical symptoms in patients.Methods: Stool samples from 36 patients with active GAD (A-GAD group) and 24 matched healthy control subjects (HC group) were analyzed by 16S rRNA gene sequencing. Anxiety was assessed with the Hamilton Anxiety Rating Scale and the Self-rating Anxiety Scale, and global assessments of functioning were performed at baseline and 1 month after drug treatment.Results: Gut microbiome compositions were altered in A-GAD patients, with fewer operational taxonomic units and lower fecal bacterial alpha-diversity. Specifically, Firmicutes and Tenericutes abundances were lower in A-GAD patients, and several genera were differentially represented in the A-GAD and HC groups. The abundances of Eubacterium_coprostanoligenes_group, Ruminococcaceae_UCG-014, and Prevotella_9 correlated negatively with the anxiety severity and positively with anxiety reduction, whereas the abundances of Bacteroides and Escherichia-Shigella were positively associated with anxiety severity. Sex, smoking, and alcohol intake influenced the gut microbiome composition.Limitations: The sample sizes were small and the stool samples were collected only at baseline; therefore, a causal association between changes in intestinal flora and disease remission was not established. Moreover, the effects of different drugs on gut microbiome composition were not investigated.Conclusions: Altered gut microbiome composition may contribute to GAD pathogenesis and remission.