ADENOSINE 3',5'-MONOPHOSPHATE IN PANCREATIC-ISLETS - GLUCOSE-INDUCED INSULIN RELEASE
ADENOSINE 3',5'-MONOPHOSPHATE IN PANCREATIC-ISLETS - GLUCOSE-INDUCED INSULIN RELEASE
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DOI：
10.1126/science.179.4073.569
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发表时间：
1973-01-01
期刊：
影响因子：
56.9
通讯作者：
GRODSKY, GM
中科院分区：
文献类型：
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作者：
CHARLES, MA;FANSKA, R;GRODSKY, GM
葡萄糖诱导的大鼠灌流胰岛胰岛素释放与胰岛3′，5 ′-单磷酸腺苷升高有关如果将3′，5 ′-单磷酸腺苷的值与茶碱或葡萄糖刺激以及茶碱加葡萄糖刺激期间的胰岛素释放进行比较，则表明3′，5 ′-单磷酸腺苷在直接刺激胰岛素释放中的作用较小，但在调节葡萄糖诱导的胰岛素释放中的作用显著。
Glucose-induced release of insulin from perifused rat islets is associated with elevated islet adenosine 3′,5′-monophosphate. If values for adenosine 3′,5′-monophosphate are compared to insulin release during theophylline or glucose stimulation and theophylline plus glucose stimulation, it suggests a minor role for adenosine 3′,5′-monophosphate in directly stimulating insulin release but a prominent role in modulating glucose-induced release of insulin.