Autophagy-associated immune responses and cancer immunotherapy.
Autophagy-associated immune responses and cancer immunotherapy.
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自噬相关的免疫反应和癌症免疫治疗。
DOI：
10.18632/oncotarget.6908
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发表时间：
2016-04-19
期刊：
影响因子：
--
通讯作者：
Sui X
中科院分区：
文献类型：
--
作者：
Pan H;Chen L;Xu Y;Han W;Lou F;Fei W;Liu S;Jing Z;Sui X
自噬是一种进化上保守的分解代谢过程，通过这种过程，细胞成分被隔离在双膜囊泡中，并传递给溶酶体进行最终降解和再循环。越来越多的证据表明，自噬在细胞存活、衰老和体内平衡中起着至关重要的作用，其失调与多种疾病有关，包括癌症、心血管疾病、神经变性。近年来的研究表明，自噬也是细胞免疫反应的重要调节因子。然而，自噬调节肿瘤免疫反应的机制尚不清楚。在这篇综述中，我们将描述自噬在免疫调节中的作用，并总结目前在自噬控制细胞免疫反应的能力方面有充分记载的可能的分子机制。此外，关于自噬在癌症免疫治疗中的潜在作用的科学和临床障碍将被讨论。
Autophagy is an evolutionarily conserved catabolic process by which cellular components are sequestered into a double-membrane vesicle and delivered to the lysosome for terminal degradation and recycling. Accumulating evidence suggests that autophagy plays a critical role in cell survival, senescence and homeostasis, and its dysregulation is associated with a variety of diseases including cancer, cardiovascular disease, neurodegeneration. Recent studies show that autophagy is also an important regulator of cell immune response. However, the mechanism by which autophagy regulates tumor immune responses remains elusive. In this review, we will describe the role of autophagy in immune regulation and summarize the possible molecular mechanisms that are currently well documented in the ability of autophagy to control cell immune response. In addition, the scientific and clinical hurdles regarding the potential role of autophagy in cancer immunotherapy will be discussed.