MR imaging-guided focused ultrasound surgery of breast cancer: correlation of dynamic contrast-enhanced MRI with histopathologic findings
MR imaging-guided focused ultrasound surgery of breast cancer: correlation of dynamic contrast-enhanced MRI with histopathologic findings
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DOI：
10.1023/b:brea.0000003956.11376.5b
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发表时间：
2003-11-01
影响因子：
3.8
通讯作者：
Boulanger, Y
中科院分区：
文献类型：
--
作者：
Gianfelice, D;Khiat, A;Boulanger, Y
目的。目的评价动态增强磁共振成像(DCE-MRI)参数在无创磁共振引导下聚焦超声乳腺肿瘤手术(MRIgFUS)术后残留肿瘤监测中的价值。对17例乳腺小肿瘤(直径3.5 cm)行MRIgFUS治疗前后的DCE-MRI资料。手术切除病变，并通过组织病理学分析确定残留肿瘤的存在。肿瘤残留率与肿瘤最大强化部位的信号强度增加值(ISI)、最大差值函数(MDF)和阳性强化积分(PEI)三项参数相关。ISI(r=0.897)、MDF(r=0.789)和PEI(r=0.859)参数与组织病理学所确定的残存肿瘤存活率之间具有良好的相关性。经受试者特征曲线分析，ISI的临界值为20%，灵敏度为77%，特异度为100%。这些结果表明，DCE-MRI数据的参数可以提供一种可靠的无创性方法来评估乳腺肿瘤MRIgFUS治疗后的残留肿瘤。
Purpose. To assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters to monitor residual tumor following non-invasive MRI-guided focused ultrasound surgery (MRIgFUS) of breast tumors.Methods. DCE-MRI data were acquired before and after the MRIgFUS treatment of small breast tumors (d < 3.5 cm) for 17 patients. The lesion was surgically resected and the presence of residual tumor was determined by histopathological analysis. The percentage of residual tumor was correlated with three DCE-MRI parameters measured at the maximally enhancing site of each tumor: increase in signal intensity (ISI), maximum difference function (MDF) and positive enhancement integral (PEI).Results. A good correlation was found between the ISI (r = 0.897), MDF ( r = 0.789) and PEI ( r = 0.859) parameters and the percentage of residual viable tumor determined by histopathology. A receiver operator characteristic curve analysis yielded a cutoff value for ISI at 20% with a sensitivity of 77% and a specificity of 100%.Conclusion. These results suggest that parameters from DCE-MRI data could provide a reliable non-invasive method for assessing residual tumor following MRIgFUS treatment of breast tumors.