A synaptonemal complex protein promotes homology-independet centromere coupling
A synaptonemal complex protein promotes homology-independet centromere coupling
复制标题
DOI：
10.1126/science.1108283
复制
发表时间：
2005-05-06
期刊：
影响因子：
56.9
通讯作者：
Roeder, GS
中科院分区：
文献类型：
--
作者：
Tsubouchi, T;Roeder, GS
我们描述了出芽酵母减数分裂细胞中的一个过程，其中染色体在着丝粒上成对地连接在一起，而不依赖于染色体同源性。这些着丝体相互作用依赖于突触复合体成分Zip1。在野生型二倍体的减数分裂过程中，着丝粒夫妇最初是非同源的，然后经历转换，直到所有的对都包含同源物。这种向同源偶联的转变依赖于Spo11，一种开始减数分裂重组所需的蛋白质。在减数分裂早期组装的突触复合体区域通常与着丝粒相关。我们认为着丝粒偶联促进了同源配对并促进了突触的启动。
We describe a process in meiotic cells of budding yeast in which chromosomes become joined together in pairs at their centromeres independent of chromosomal homology. These centromeric interactions depend on the synaptonemal complex component Zip1. During meiosis in wild-type diploids, centromere couples are initially nonhomologous and then undergo switching until all couples involve homologs. This transition to homologous coupling depends on Spo11, a protein required for the initiation of meiotic recombination. Regions of synaptonemal complex assembled early in meiosis are often centromere-associated. We propose that centromere coupling facilitates homolog pairing and promotes synapsis initiation.