MOLECULAR-CLONING OF THE ZETA-CHAIN OF THE T-CELL ANTIGEN RECEPTOR
MOLECULAR-CLONING OF THE ZETA-CHAIN OF THE T-CELL ANTIGEN RECEPTOR
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DOI：
10.1126/science.3278377
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发表时间：
1988-02-26
期刊：
影响因子：
56.9
通讯作者：
KLAUSNER, RD
中科院分区：
文献类型：
--
作者：
WEISSMAN, AM;BANIYASH, M;KLAUSNER, RD
T细胞抗原受体是一种多亚单位受体复合物，存在于所有成熟和许多发育中的T细胞表面。它由克隆型异二聚体组成，非共价连接到由四个基因编码的五条不变链，称为CD3复合物。CD3的γ链，δ链和ε链已经被分子表征。在这个报告中，分子克隆的互补DNA编码的zeta链的小鼠T细胞抗原受体描述。预测的zeta链的蛋白质序列表明其结构不同于任何先前描述的受体亚基。
The T cell antigen receptor is a multi-subunit receptor complex present on the surface of all mature and many developing T cells. It consists of clonotypic heterodimers noncovalently linked to five invariant chains that are encoded by four genes and referred to as the CD3 complex. The CD3 gamma, delta, and epsilon chains have been molecularly characterized. In this report the molecular cloning of a complementary DNA encoding the zeta chain of the murine T cell antigen receptor is described. The predicted protein sequence of the zeta chain suggests a structure distinct from those of any of the previously described receptor subunits.