Health and reproductive experiences of women with an FMR1 premutation with and without fragile X premature ovarian insufficiency.
Health and reproductive experiences of women with an FMR1 premutation with and without fragile X premature ovarian insufficiency.
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DOI：
10.3389/fgene.2014.00300
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发表时间：
2014
影响因子：
3.7
通讯作者：
Bailey DB Jr
中科院分区：
文献类型：
--
作者：
Wheeler AC;Raspa M;Green A;Bishop E;Bann C;Edwards A;Bailey DB Jr
最近，研究表明，FMR 1扩增的女性出现更大的医疗和情感并发症以及身体健康症状的风险增加。然而，这些研究通常在模拟与这些症状相关的多个风险因素的能力方面受到限制，这些风险因素仅限于少数参与者（n = 112-146）。本研究采用调查方法，检查了458名成年女性的健康经历，这些女性有或没有脆性X原发性卵巢功能不全（FXPOI）诊断史。结果表明类似的调查结果，在文献中报道的频率方面的医疗，情感和生殖经验的妇女与前突变。除了预期的生殖差异外，诊断为FXPOI的女性也比未诊断为FXPOI的女性更容易出现头晕，恶心和肌肉无力。与一般人群相比，患有和不患有FXPOI的女性更有可能使用生殖辅助，并且在至少一次妊娠期间更有可能经历先兆子痫。抑郁和焦虑并存预示着医疗条件的增加和日常身体健康症状的增加。
Recently, research has indicated an increased risk for greater medical and emotional comorbidity and physical health symptoms among women with an FMR1 expansion. However, these studies have generally been limited in their ability to model multiple risk factors associated with these symptoms by small numbers (n = 112–146) of participants. This study used survey methodology to examine the health experiences of 458 adult women with the premutation with and without a history of a fragile X primary ovarian insufficiency (FXPOI) diagnosis. Results suggest similar findings to those reported in the literature with regard to the frequency of medical, emotional, and reproductive experiences of women with the premutation. In addition to expected reproductive differences, women with a diagnosis of FXPOI were also more likely to experience dizziness, nausea, and muscle weakness than women without a diagnosis of FXPOI. Women with and without FXPOI were more likely to have used reproductive assistance and were more likely to have experienced preeclampsia during at least one pregnancy than is reported in the general population. Having comorbid depression and anxiety was predictive of increased medical conditions and increased daily physical health symptoms.