BLOOD PYRUVATE AND PLASMA GLUCOSE LEVELS DURING ORAL AND INTRAVENOUS GLUCOSE TOLERANCE TESTS IN OBESE AND NON-OBESE WOMEN
BLOOD PYRUVATE AND PLASMA GLUCOSE LEVELS DURING ORAL AND INTRAVENOUS GLUCOSE TOLERANCE TESTS IN OBESE AND NON-OBESE WOMEN
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DOI：
10.1016/0026-0495(68)90053-x
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发表时间：
1968-01-01
影响因子：
9.8
通讯作者：
CRAMP, DG
中科院分区：
文献类型：
--
作者：
DOAR, JWH;WYNN, V;CRAMP, DG
本文描述了98名女性口服/静脉注射GLU前后静脉血丙酮酸[PYR]和血浆葡萄糖[GLU]水平的研究，其中27名为肥胖。肥胖组和非肥胖组空腹血浆GLU水平和静脉GLU耐量相似。然而，肥胖组口服GLU耐受性受损。在口服/静脉注射GLU前后，肥胖组的平均血PYR水平均升高。虽然口服/静脉PYR曲线下的总面积增加，但肥胖组在禁食基线以上的增量面积没有显著增加。在某些GLU耐量正常的肥胖受试者中观察到血PYR水平升高。空腹血PYR和口服/静脉血PYR曲线下面积与肥胖程度的相关性优于与GLU耐量的相关性。无法确定肥胖受试者血液中PYR水平升高是由于PYR去除受损还是形成增加。
Studies of venous blood pyruvate [PYR] and plasma glucose [GLU] levels before and after the administration of oral/intravenous GLU are described in a group of 98 women, 27 of whom were obese. The fasting plasma GLU level and intravenous GLU tolerance were similar in obese and non-obese groups. Oral GLU tolerance, however, was impaired in the obese group. The mean blood PYR level was elevated in the obese group, both before and after oral/intravenous GLU administration. While the total area under the oral/intravenous PYR curve was increased, the incremental area above the fasting base line was not significantly greater in the obese group. Elevated blood PYR levels were observed in certain obese subjects whose GLU tolerance was normal. The fasting blood PYR, and area under the oral/intravenous blood PYR curve, correlated better with the degree of obesity than with GLU tolerance. It was not possible to determine whether the elevated blood PYR levels in obese subjects were due to impaired PYR removal or increased formation.