Aminoglycoside Functionalization as a Tool for Targeting Nucleic Acids.
Aminoglycoside Functionalization as a Tool for Targeting Nucleic Acids.
复制标题
氨基糖苷功能化作为靶向核酸的工具。
DOI：
10.1007/978-1-4939-9216-4_9
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Arya,DevP
中科院分区：
文献类型：
--
作者：
Watkins,Derrick;Maiti,Krishnagopal;Arya,DevP
Aminoglycoside functionalization as a tool for targeting natural and unnatural nucleic acids holds great promise in their development as diagnostic probes and medicinally relevant compounds. Simple synthetic procedures designed to easily and quickly manipulate amino sugar (neomycin, kanamycin) to more powerful and selective ligands are presented in this chapter. We describe representative procedures for (a) aminoglycoside conjugation and (b) preliminary screening for their nucleic acid binding and selectivity.
