Interactions of aromatic amino acids with gastric secretagogues in humans.
Interactions of aromatic amino acids with gastric secretagogues in humans.
复制标题
芳香氨基酸与人类胃促分泌剂的相互作用。
DOI：
10.1016/0016-5085(88)90616-6
复制
发表时间：
1988
期刊：
影响因子：
29.4
通讯作者：
H. Greten
中科院分区：
文献类型：
--
作者：
H. Lenz;T. Struck;H. Greten
To determine the interactions of phenylalanine and tryptophan with gastric secretagogues, acid secretory studies were performed in 10 healthy subjects. Phenylalanine and tryptophan potentiated the gastric secretory responses following low doses of pentagastrin, whereas their effects on acid secretion stimulated by low doses of histamine or the cholinergic bethanecol were additive. Phenylalanine and tryptophan did not increase maximal acid output stimulated by pentagastrin, histamine, or bethanecol. Doses of the H2-receptor antagonist ranitidine, the prostaglandin E1analogue misoprostol, atropine, and somatostatin that produced ≈50% inhibition of pentagastrin-stimulated acid secretion significantly inhibited phenylalanine- and tryptophan-stimulated acid secretion. After the combination of either phenylalanine or tryptophan with pentagastrin, the H2-receptor antagonist significantly inhibited gastric acid secretion, whereas somatostatin, atropine, and the prostaglandin E1analogue were not effective. These results indicate that both phenylalanine and tryptophan potentiate gastric acid secretion stimulated by a submaximal dose of pentagastrin, whereas their effects on histamine- and bethanecol-stimulated secretion are additive. The potentiating effects of phenylalanine and tryptophan on pentagastrin-stimulated acid secretion depend, at least in part, on intact histamine pathways.
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DOI：
10.1152/ajpgi.1982.242.5.g504
发表时间：
1982
期刊：
The American journal of physiology
影响因子：
--
作者：
Chew,CS;Hersey,SJ
通讯作者：
Hersey,SJ
门静脉分流术的肝硬化患者胃酸分泌对胃泌素的敏感性增加。
DOI：
10.1172/jci112927
发表时间：
1987
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Lenz,HJ;Struck,T;Greten,H;Koss,MA;Eysselein,VE;Walsh,JH;Isenberg,JI
通讯作者：
Isenberg,JI
影响因子：
15.9
作者：
MCARTHUR, KE;ISENBERG, JI;DREIER, SJ
通讯作者：
DREIER, SJ
胃刺激剂对分离的犬壁细胞[14 C]氨基比林积累的增强相互作用。
影响因子：
29.4
作者：
Soll,AH
通讯作者：
Soll,AH
有或没有门静脉分流的人类胃酸分泌的肠期。
影响因子：
29.4
作者：
Lenz,HJ;Hogan,DL;Isenberg,JI
通讯作者：
Isenberg,JI