Effects of wheat bran extract rich in arabinoxylan oligosaccharides and resistant starch on overnight glucose tolerance and markers of gut fermentation in healthy young adults
Effects of wheat bran extract rich in arabinoxylan oligosaccharides and resistant starch on overnight glucose tolerance and markers of gut fermentation in healthy young adults
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DOI：
10.1007/s00394-015-0985-z
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发表时间：
2016-06-01
影响因子：
5
通讯作者：
Ostman, Elin M.
中科院分区：
文献类型：
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作者：
Boll, Elin V. Johansson;Ekstrom, Linda M. N. K.;Ostman, Elin M.
目的膳食纤维（DF）的特定组合已被观察到在随后的标准化早餐中导致葡萄糖耐量的改善。Arabinoxylan oligosaccharies （AXOS）被认为是一种具有益生元潜力的DF，但迄今为止尚未有研究调查其在人体中的代谢作用。这项随机交叉研究评估了含有富含axos的麦麸提取物和抗性淀粉（RS, Hi-Maize）的面包单独或组合对健康受试者葡萄糖耐量、相关代谢参数和肠道发酵标志物的夜间影响。方法夜间对照和试验产品为：(1)对照白面粉面包，白面粉面包中添加(2)AXOS和RS (WWB + AXOS + RS),(3)增加AXOS （WWB + hiAXOS）或(4)RS （WWB + hiRS）含量。在随后的标准化早餐中，取血3小时监测血糖、胰岛素、非酯化脂肪酸、胰高血糖素样肽(GLP)-1和GLP-2。测定呼吸氢（H-2）和短链脂肪酸（SCFA）作为肠道发酵的标志物，并使用视觉模拟量表评定主观食欲。结果在3小时内，随着AXOS的增加，葡萄糖反应呈剂量依赖性降低。胰岛素敏感性指数在WWB + hiAXOS晚餐后的早晨有所改善。在两顿含有AXOS的晚餐后，早晨观察到呼吸H-2浓度和循环SCFA的增加。结论本研究表明，AXOS具有改善夜间葡萄糖耐量的潜力，其机制可能是改善胰岛素敏感性和增加肠道发酵。
Purpose Specific combinations of dietary fiber (DF) have been observed to result in improved glucose tolerance at a subsequent standardized breakfast. Arabinoxylan oligosaccharides (AXOS) are considered as DF with prebiotic potential, but so far no studies have investigated their metabolic effects in humans. This randomized cross-over study evaluated the overnight impact of breads containing AXOS-rich wheat bran extract and resistant starch (RS, Hi-Maize), separately or combined, on glucose tolerance, related metabolic parameters and markers of gut fermentation in healthy subjects.Methods Evening reference and test products were: (1) reference white wheat flour bread (WWB), WWB supplemented with (2) AXOS and RS (WWB + AXOS + RS), (3) an increased content of either AXOS (WWB + hiAXOS) or (4) RS (WWB + hiRS). At the subsequent standardized breakfast, blood was sampled for 3 h to monitor glucose, insulin, nonesterified fatty acids, glucagon-like peptide (GLP)-1 and GLP-2. Breath hydrogen (H-2) and short chain fatty acids (SCFA) were measured as markers of gut fermentation, and subjective appetite was rated using visual analog scales.Results Dose-dependent decreases in glucose responses were observed with increased AXOS over the duration of 3 h. Insulin sensitivity index was improved in the morning after the WWB + hiAXOS evening meal. An increase in breath H-2 concentration and circulating SCFA was observed in the morning after both evening meals containing AXOS.Conclusion The present study indicates that AXOS have the potential of improving glucose tolerance in an overnight perspective and suggested mechanisms are improved insulin sensitivity and increased gut fermentation.