Mediating lipid biosynthesis: implications for cardiovascular disease.
Mediating lipid biosynthesis: implications for cardiovascular disease.
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DOI：
10.1016/j.tcm.2013.03.002
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发表时间：
2013-10
影响因子：
9.3
通讯作者：
Yang F
中科院分区：
文献类型：
--
作者：
Xiaoli;Yang F
脂质平衡失调是心血管疾病的危险因素之一。因此，了解维持脂质稳态的分子机制可能有助于发现治疗CVD的新靶点。MED15和细胞周期蛋白依赖性激酶-8(CDK8)是介体复合体的亚基，含有多种蛋白质，具有转录辅助因子的功能。介体可以正向或负向地调节基因的表达，这取决于上下文及其相关的转录因子。最近的研究表明，MED15和CDK8在调节固醇调节元件结合蛋白(SREBP)转录因子中起着关键作用，而SREBP转录因子是负责脂质生物合成的基因的主要激活因子。在这里，我们回顾了MED15和CDK8在调节脂质平衡中的作用，并讨论了其在心血管疾病中的意义。
Dysregulation of lipid homeostasis is a risk factor for cardiovascular disease (CVD). Thus, understanding the molecular mechanisms of maintaining lipid homeostasis may aid the discovery of novel targets for treating CVD. MED15 and Cyclin-dependent kinase-8 (CDK8) are subunits of the Mediator complex, which contains multiple proteins and functions as a transcriptional cofactor. Mediator can positively or negatively regulate gene expression, depending on the contexts and its associated transcription factors. Recent studies revealed a critical role of MED15 and CDK8 in regulating sterol regulatory element-binding protein (SREBP) transcription factors, which are master activators for genes that are responsible for lipid biosynthesis. Here, we review the function of MED15 and CDK8 in regulating lipid homeostasis and discuss the implications for CVD.