Association of LTBR polymorphisms with chronic hepatitis B virus infection and hepatitis B virus-related hepatocellular carcinoma
Association of LTBR polymorphisms with chronic hepatitis B virus infection and hepatitis B virus-related hepatocellular carcinoma
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LTBR多态性与慢性乙型肝炎病毒感染及乙型肝炎病毒相关性肝细胞癌的关系
DOI：
10.1016/j.intimp.2017.05.031
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发表时间：
2017-08-01
影响因子：
5.6
通讯作者：
Liu，Zhengwen
中科院分区：
文献类型：
--
作者：
Zhu，Qianqian;Li，Fang;Liu，Zhengwen
光敏素β受体（LTβR）信号通路参与了B型肝炎病毒（HBV）感染、肝炎和肝癌的发生。然而，LTBR基因多态性与HBV感染之间的潜在联系尚不清楚。本研究旨在探讨LTBR基因多态性与慢性HBV感染及HBV相关性肝细胞癌（HCC）的关系。该研究包括409例慢性HBV感染患者，73例HBV感染消退者和197例健康对照。采用聚合酶链反应-连接酶检测反应方法对rs 12354和rs3759333两个多态性位点进行基因分型。HBV感染缓解者rs 12354基因型GT和等位基因T的频率显著高于慢性HBV感染者和健康对照者（GT基因型分别为38.4%vs22.2%，38.4%vs20.8%，P = 0.004和P = 0.004; T等位基因：20.5%vs13.1%，20.5%vs12.9%，P = 0.017和P = 0.028）。rs3759333基因型和等位基因频率在HBV感染者、HBV感染缓解者和健康对照者之间差异无统计学意义。rs 12354和rs3759333的基因型和等位基因频率在慢性B型肝炎和HBV相关性肝癌患者之间差异无统计学意义。携带rs 12354和rs3759333基因型的HBV相关HCC患者血清LTβR水平和总生存率差异无统计学意义。这些结果表明LTBRrs 12354多态性可能与HBV感染的自发消退有关。需要更多的大样本研究来证实和扩展这些发现。
Lymphotoxin-β receptor (LTβR) signaling is involved in hepatitis B virus (HBV) infection, hepatitis and liver carcinogenesis. However, the potential association betweenLTBRpolymorphisms and HBV infection remains unclear. This study investigated the associations betweenLTBRpolymorphisms and chronic HBV infection and HBV-related hepatocellular carcinoma (HCC). The study included 409 patients with chronic HBV infection, 73 HBV infection resolvers, and 197 healthy controls. Two polymorphisms rs12354 and rs3759333 were selected and genotyped by polymerase chain reaction-ligase detection reaction method. The frequencies of rs12354 genotype GT and allele T in HBV infection resolvers were significantly higher than those in patients with chronic HBV infection and healthy controls (genotype GT: 38.4% vs. 22.2% and 38.4% vs. 20.8%,P= 0.004 andP= 0.004, respectively; allele T: 20.5% vs. 13.1% and 20.5% vs. 12.9%,P= 0.017 andP= 0.028, respectively). The frequencies of rs3759333 genotypes and alleles between HBV patients, HBV infection resolvers and healthy controls had no statistical difference. The genotype and allele frequencies of rs12354 and rs3759333 had no statistical differences between chronic hepatitis B and HBV-related HCC patients. The serum LTβR levels and the overall survival rate between HBV-related HCC patients carrying different rs12354 and rs3759333 genotypes had no statistical differences. These results suggest that theLTBRrs12354 polymorphism might be associated with the spontaneous resolution of HBV infection. Additional studies with large sample size are needed to confirm and extend these findings.