In vivo assessment of arsenic bioavailability in rice and its significance for human health risk assessment.
In vivo assessment of arsenic bioavailability in rice and its significance for human health risk assessment.
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DOI：
10.1289/ehp.9322
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发表时间：
2006-12
影响因子：
10.4
通讯作者：
Naidu R
中科院分区：
文献类型：
--
作者：
Juhasz AL;Smith E;Weber J;Rees M;Rofe A;Kuchel T;Sansom L;Naidu R
全世界有数百万人食用砷污染的大米;然而，人们对摄入砷污染大米后砷的吸收和生物利用度知之甚少。在这项研究中，我们评估了砷的形态在温室种植和超市购买的大米，并确定砷的生物利用度在煮熟的米饭使用体内猪模型。在超市购买的大米中，砷完全以无机形式存在，而温室种植的大米（使用受砷酸钠污染的灌溉水）中，大部分（~ 86%）砷以二甲基胂酸（有机砷）形式存在。由于二甲基胂酸的绝对生物利用率低，而温室水稻中二甲基胂酸的比例较高，因此水稻结合砷的生物可利用率仅为33 ± 3%（平均值± SD）。相反，在超市购买的用砷酸钠污染的水煮的米饭中，砷完全以无机形式存在，生物利用度很高（89 ± 9%）。这些结果表明，砷在水稻中的生物利用度是高度依赖于砷的形态，这反过来又可以根据水稻品种，灌溉水中的砷，以及砷形态的存在和性质在烹饪水中。因此，在估计食用用砷污染水种植和烹饪的大米的暴露量时，砷的形态和生物利用度是减少不确定性的关键参数。
Millions of people worldwide consume arsenic-contaminated rice; however, little is known about the uptake and bioavailability of arsenic species after arsenic-contaminated rice ingestion. In this study, we assessed arsenic speciation in greenhouse-grown and supermarket-bought rice, and determined arsenic bioavailability in cooked rice using an in vivo swine model. In supermarket-bought rice, arsenic was present entirely in the inorganic form compared to greenhouse-grown rice (using irrigation water contaminated with sodium arsenate), where most (~ 86%) arsenic was present as dimethylarsinic acid (organic arsenic). Because of the low absolute bioavailability of dimethylarsinic acid and the high proportion of dimethylarsinic acid in greenhouse-grown rice, only 33 ± 3% (mean ± SD) of the total rice-bound arsenic was bioavailable. Conversely, in supermarket-bought rice cooked in water contaminated with sodium arsenate, arsenic was present entirely in the inorganic form, and bioavailability was high (89 ± 9%). These results indicate that arsenic bioavailability in rice is highly dependent on arsenic speciation, which in turn can vary depending on rice cultivar, arsenic in irrigation water, and the presence and nature of arsenic speciation in cooking water. Arsenic speciation and bioavailability are therefore critical parameters for reducing uncertainties when estimating exposure from the consumption of rice grown and cooked using arsenic-contaminated water.
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影响因子：
11.4
作者：
Abedin, MJ;Cresser, MS;Cotter-Howells, J
通讯作者：
Cotter-Howells, J
影响因子：
--
作者：
Chakraborti, D;Sengupta, MK;Quamruzzaman, Q
通讯作者：
Quamruzzaman, Q
影响因子：
4.9
作者：
Abedin, MJ;Cotter-Howells, J;Meharg, AA
通讯作者：
Meharg, AA
影响因子：
6.1
作者：
Akter, KF;Chen, Z;Naidu, R
通讯作者：
Naidu, R
影响因子：
6.5
作者：
Baffes, J;Gautam, M
通讯作者：
Gautam, M